125799 20241125101136.0 doi 10.3390/vetsci10040245 sideral 133366 ART-2023-133366 eng García-Belenguer, Sylvia Universidad de Zaragoza (orcid)0000-0001-5084-6555 Effect of a Ketogenic medium chain Triglyceride-enriched diet on the fecal microbiota in canine idiopathic epilepsy: a pilot study 2023 Access copy available to the general public Unrestricted Ketogenic diets have been successfully used in people and dogs with idiopathic epilepsy. This study examined the effect of a ketogenic medium chain triglycerides (MCT)- enriched diet administered for one month on the fecal microbiota of epileptic (n = 11) (six with drug-sensitive epilepsy, DSE; five with drug-refractory epilepsy, DRE) and non-epileptic beagle dogs (n = 12). A significant reduction after diet in the relative abundance of bacteria from the Actinobacteria phylum was observed in all dogs. Epileptic dogs showed a higher relative abundance of Lactobacillus compared with non-epileptic dogs at baseline but these differences disappeared after diet. Epileptic dogs also showed a significantly higher abundance of Negativicutes and Selenomonadales after dietary intervention. Baseline microbiota patterns were similar in non-epileptic beagles and dogs with DSE but significantly different from dogs with DRE. In non-epileptic and DSE groups, the MCT diet decreased the relative abundance of Firmicutes and increased that of Bacteroidetes and Fusobacteria, but the opposite effect was observed in dogs with DRE. These results suggest that the MCT diet effect would depend on individual baseline microbiota patterns and that ketogenic diets could help reduce gut microbiota differences between dogs with DRE and DSE. info:eu-repo/grantAgreement/ES/DGA/LMP134-21 info:eu-repo/grantAgreement/ES/UZ/UZ2019-BIO-03 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 2.0 2023 VETERINARY SCIENCES 43 / 167 = 0.257 2023 Q2 T1 0.552 2023 Veterinary (miscellaneous) 2023 Q1 2.9 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Grasa, Laura Universidad de Zaragoza (orcid)0000-0002-5306-9365 Palacio, Jorge Universidad de Zaragoza (orcid)0000-0002-1581-3085 Moral, Jon Universidad de Zaragoza Rosado, Belén Universidad de Zaragoza (orcid)0000-0003-1728-900X 1012 410 Universidad de Zaragoza Dpto. Farmac.Fisiol.y Med.L.F. Área Fisiología 1009 617 Universidad de Zaragoza Dpto. Patología Animal Área Medicina y Cirugía Animal 10, 4 (2023), 245 [13 pp.] Veterinary Sciences 2306-7381 1747844 http://zaguan.unizar.es/record/125799/files/texto_completo.pdf Versión publicada 2733542 http://zaguan.unizar.es/record/125799/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:125799 articulos driver 2024-11-22-12:01:05 ARTICLE