000125804 001__ 125804
000125804 005__ 20241125101138.0
000125804 0247_ $$2doi$$a10.3390/cimb45040232
000125804 0248_ $$2sideral$$a133371
000125804 037__ $$aART-2023-133371
000125804 041__ $$aeng
000125804 100__ $$0(orcid)0000-0002-2455-680X$$aLópez-Pingarrón, L.$$uUniversidad de Zaragoza
000125804 245__ $$aInterstitial cells of Cajal and enteric nervous system in gastrointestinal and neurological pathology. Relation to oxidative stress
000125804 260__ $$c2023
000125804 5060_ $$aAccess copy available to the general public$$fUnrestricted
000125804 5203_ $$aThe enteric nervous system (ENS) is organized into two plexuses—submucosal and myenteric—which regulate smooth muscle contraction, secretion, and blood flow along the gastrointestinal tract under the influence of the rest of the autonomic nervous system (ANS). Interstitial cells of Cajal (ICCs) are mainly located in the submucosa between the two muscle layers and at the intramuscular level. They communicate with neurons of the enteric nerve plexuses and smooth muscle fibers and generate slow waves that contribute to the control of gastrointestinal motility. They are also involved in enteric neurotransmission and exhibit mechanoreceptor activity. A close relationship appears to exist between oxidative stress and gastrointestinal diseases, in which ICCs can play a prominent role. Thus, gastrointestinal motility disorders in patients with neurological diseases may have a common ENS and central nervous system (CNS) nexus. In fact, the deleterious effects of free radicals could affect the fine interactions between ICCs and the ENS, as well as between the ENS and the CNS. In this review, we discuss possible disturbances in enteric neurotransmission and ICC function that may cause anomalous motility in the gut.
000125804 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000125804 590__ $$a2.8$$b2023
000125804 592__ $$a0.675$$b2023
000125804 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b184 / 313 = 0.588$$c2023$$dQ3$$eT2
000125804 593__ $$aMedicine (miscellaneous)$$c2023$$dQ2
000125804 593__ $$aMicrobiology$$c2023$$dQ2
000125804 593__ $$aMicrobiology (medical)$$c2023$$dQ2
000125804 593__ $$aMolecular Biology$$c2023$$dQ3
000125804 594__ $$a2.9$$b2023
000125804 655_4 $$ainfo:eu-repo/semantics/review$$vinfo:eu-repo/semantics/publishedVersion
000125804 700__ $$aAlmeida, H.
000125804 700__ $$0(orcid)0000-0002-6001-2738$$aSoria-Aznar, M.$$uUniversidad de Zaragoza
000125804 700__ $$0(orcid)0000-0002-2323-2053$$aReyes-Gonzales, M. C.$$uUniversidad de Zaragoza
000125804 700__ $$aRodríguez-Moratinos, A. B.
000125804 700__ $$aMuñoz-Hoyos, A.
000125804 700__ $$0(orcid)0000-0001-9507-6478$$aGarcía, J. J.$$uUniversidad de Zaragoza
000125804 7102_ $$11012$$2410$$aUniversidad de Zaragoza$$bDpto. Farmac.Fisiol.y Med.L.F.$$cÁrea Fisiología
000125804 773__ $$g45, 4 (2023), 3552-3572$$pCurr. issues mol. biol.$$tCURRENT ISSUES IN MOLECULAR BIOLOGY$$x1467-3037
000125804 8564_ $$s2710743$$uhttps://zaguan.unizar.es/record/125804/files/texto_completo.pdf$$yVersión publicada
000125804 8564_ $$s2569145$$uhttps://zaguan.unizar.es/record/125804/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000125804 909CO $$ooai:zaguan.unizar.es:125804$$particulos$$pdriver
000125804 951__ $$a2024-11-22-12:01:32
000125804 980__ $$aARTICLE