000125823 001__ 125823
000125823 005__ 20240731103356.0
000125823 0247_ $$2doi$$a10.1039/d3dt00079f
000125823 0248_ $$2sideral$$a133181
000125823 037__ $$aART-2023-133181
000125823 041__ $$aeng
000125823 100__ $$aSalvador-Gil, Daniel
000125823 245__ $$aCatalysis-free synthesis of thiazolidine–thiourea ligands for metal coordination (Au and Ag) and preliminary cytotoxic studies
000125823 260__ $$c2023
000125823 5060_ $$aAccess copy available to the general public$$fUnrestricted
000125823 5203_ $$aThe reaction of propargylamines with isothiocyanates results in the selective formation of iminothiazolidines, aminothiazolines or mixed thiazolidine–thiourea compounds under mild conditions. It has been observed that secondary propargylamines lead to the selective formation of cyclic 2-amino-2-thiazoline derivatives, while primary propargylamines form iminothiazoline species. In addition, these cyclic thiazoline derivatives can further react with an excess of isothiocyanate to give rise to thiazolidine–thiourea compounds. These species can also be achieved by reaction of propargylamines with isothiocynates in a molar ratio of 1 : 2. Coordination studies of these heterocyclic species towards silver and gold with different stoichiometries have been carried out and complexes of the type [ML(PPh3)]OTf, [ML2]OTf (M = Ag, Au) or [Au(C6F5)L] have been synthesised. Preliminary studies of the cytotoxic activity in lung cancer cells have also been performed in both ligands and complexes, showing that although the ligands do not exhibit anticancer activity, their coordination to metals, especially silver, greatly enhances the cytotoxic activity.
000125823 536__ $$9info:eu-repo/grantAgreement/ES/AEI/PID2019-104379RB-C21$$9info:eu-repo/grantAgreement/ES/AEI/PID2020-117455GB-I00$$9info:eu-repo/grantAgreement/ES/DGA-FSE/E07-20R$$9info:eu-repo/grantAgreement/ES/MICINN-AEI/RED2018-102471-T
000125823 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000125823 590__ $$a3.5$$b2023
000125823 592__ $$a0.697$$b2023
000125823 591__ $$aCHEMISTRY, INORGANIC & NUCLEAR$$b13 / 44 = 0.295$$c2023$$dQ2$$eT1
000125823 593__ $$aInorganic Chemistry$$c2023$$dQ1
000125823 594__ $$a6.6$$b2023
000125823 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000125823 700__ $$0(orcid)0000-0002-5244-9569$$aP. Herrera, Raquel
000125823 700__ $$0(orcid)0000-0003-0553-0695$$aGimeno, M. Concepción
000125823 773__ $$g23, 52 (2023), 7797-7808$$pDalton Trans.$$tDalton Transactions$$x1477-9226
000125823 8564_ $$s2451091$$uhttps://zaguan.unizar.es/record/125823/files/texto_completo.pdf$$yVersión publicada
000125823 8564_ $$s2147579$$uhttps://zaguan.unizar.es/record/125823/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000125823 909CO $$ooai:zaguan.unizar.es:125823$$particulos$$pdriver
000125823 951__ $$a2024-07-31-09:56:55
000125823 980__ $$aARTICLE