125854 20241125101154.0 doi 10.3390/math11081824 sideral 133329 ART-2023-133329 eng Urdeitx, Pau Universidad de Zaragoza (orcid)0000-0001-6727-563X Multiple myeloma cell simulation using an agent-based framework coupled with a continuous fluid model 2023 Access copy available to the general public Unrestricted Bone marrow mechanical conditions play a key role in multiple myeloma cancer. The complex mechanical and chemical conditions, as well as the interactions with other resident cells, hinder the development of effective treatments. Agent-based computational models, capable of defining the specific conditions for every single cell, can be a useful tool to identify the specific tumor microenvironment. In this sense, we have developed a novel hybrid 3D agent-based model with coupled fluid and particle dynamics to study multiple myeloma cells’ growth. The model, which considers cell–cell interactions, cell maturation, and cell proliferation, has been implemented by employing user-defined functions in the commercial software Fluent. To validate and calibrate the model, cell sedimentation velocity and cell proliferation rates have been compared with in vitro results, as well as with another previously in-house developed model. The results show that cell proliferation increased as cell–cell, and cell–extracellular matrix interactions increased, as a result of the reduction n maturation time. Cells in contact form cell aggregates, increasing cell–cell interactions and thus cell proliferation. Saturation in cell proliferation was observed when cell aggregates increased in size and the lack of space inhibited internal cells’ proliferation. Compared with the previous model, a huge reduction in computational costs was obtained, allowing for an increase in the number of simulated cells. info:eu-repo/grantAgreement/ES/DGA-FSE/T24-20R info:eu-repo/grantAgreement/ES/MICINN/PID2019-106099RB-C41-AEI-10.13039-501100011033 info:eu-repo/grantAgreement/ES/MICINN/PID2019-106099RB-C44 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 2.3 2023 MATHEMATICS 21 / 490 = 0.043 2023 Q1 T1 0.475 2023 Engineering (miscellaneous) 2023 Q2 Mathematics (miscellaneous) 2023 Q2 Computer Science (miscellaneous) 2023 Q2 4.0 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Clara-Trujillo, Sandra Gomez Ribelles, Jose Luis Doweidar, Mohamed H. Universidad de Zaragoza (orcid)0000-0003-0088-7222 5004 605 Universidad de Zaragoza Dpto. Ingeniería Mecánica Área Mec.Med.Cont. y Teor.Est. 11, 8 (2023), 1824 [13 pp.] Mathematics (Basel) Mathematics 2227-7390 2080899 http://zaguan.unizar.es/record/125854/files/texto_completo.pdf Versión publicada 2563658 http://zaguan.unizar.es/record/125854/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:125854 articulos driver 2024-11-22-12:08:24 ARTICLE