000125857 001__ 125857
000125857 005__ 20241125101156.0
000125857 0247_ $$2doi$$a10.1016/j.mrrev.2023.108453
000125857 0248_ $$2sideral$$a133342
000125857 037__ $$aART-2023-133342
000125857 041__ $$aeng
000125857 100__ $$aDomenech, J.
000125857 245__ $$aInsights into the potential carcinogenicity of micro- and nano-plastics
000125857 260__ $$c2023
000125857 5060_ $$aAccess copy available to the general public$$fUnrestricted
000125857 5203_ $$aThere is a growing concern regarding the potential health effects that continuous exposure to environmental micro- and nano-plastics (MNPLs) may cause on humans. Due to their persistent nature, MNPLs may accumulate in different organs and tissues and may induce in the long term the development of cancer. The present study aimed to review the existing literature on the carcinogenic potential of MNPLs. As studies directly assessing carcinogenicity were expected to be scarce, studies dealing with indirect outcomes associated with the carcinogenic process were considered in the literature search. Of the 126 studies screened, 19 satisfied the inclusion criteria. Besides, 7 additional cross-referenced articles, identified through a careful reading of the previously selected papers, also met the inclusion criteria and, consequently, were included in the review. Most of the selected studies were performed using in vitro models whereas about 40% of the studies were done in rodents, although none of them included a 2-year carcinogenicity assay. Most of the reviewed studies pointed out the potential of MNPLs to induce inflammation and genotoxicity, the latter being recognized as a strong predictor of carcinogenicity. These, along with other important findings such as the MNPLs’ ability to accumulate into cells and tissues, or their capacity to induce fibrosis, may suggest an association between MNPLs exposures and the carcinogenic potential. Nevertheless, the limited number of available studies precludes reaching clear conclusions. Therefore, this review also provides several recommendations to cover the current knowledge gaps and address the future evaluation of the MNPLs’ carcinogenic risk.
000125857 536__ $$9info:eu-repo/grantAgreement/EC/H2020/965196/EU/Innovative tools to study the impact and mode of action of micro and nanoplastics on human health: towards a knowledge base for risk assessment/PLASTICHEAL$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 965196-PLASTICHEAL
000125857 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000125857 590__ $$a6.4$$b2023
000125857 592__ $$a1.778$$b2023
000125857 591__ $$aBIOTECHNOLOGY & APPLIED MICROBIOLOGY$$b21 / 174 = 0.121$$c2023$$dQ1$$eT1
000125857 593__ $$aHealth, Toxicology and Mutagenesis$$c2023$$dQ1
000125857 591__ $$aTOXICOLOGY$$b7 / 106 = 0.066$$c2023$$dQ1$$eT1
000125857 593__ $$aGenetics$$c2023$$dQ1
000125857 591__ $$aGENETICS & HEREDITY$$b21 / 191 = 0.11$$c2023$$dQ1$$eT1
000125857 594__ $$a12.2$$b2023
000125857 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000125857 700__ $$aAnnangi, B.
000125857 700__ $$aMarcos, R.
000125857 700__ $$aHernández, A.
000125857 700__ $$0(orcid)0000-0003-2936-242X$$aCatalán, J.$$uUniversidad de Zaragoza
000125857 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética
000125857 773__ $$g791 (2023), 108453 [14 pp.]$$pMutat. res., Rev. mutat. res.$$tMUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH$$x1383-5742
000125857 8564_ $$s1126032$$uhttps://zaguan.unizar.es/record/125857/files/texto_completo.pdf$$yVersión publicada
000125857 8564_ $$s2589217$$uhttps://zaguan.unizar.es/record/125857/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000125857 909CO $$ooai:zaguan.unizar.es:125857$$particulos$$pdriver
000125857 951__ $$a2024-11-22-12:09:24
000125857 980__ $$aARTICLE