000125926 001__ 125926
000125926 005__ 20241125101150.0
000125926 0247_ $$2doi$$a10.3390/biomedicines11020502
000125926 0248_ $$2sideral$$a133423
000125926 037__ $$aART-2023-133423
000125926 041__ $$aeng
000125926 100__ $$aRódenas-González, Francisco
000125926 245__ $$aVicarious social defeat increases conditioned rewarding effects of cocaine and ethanol intake in female mice
000125926 260__ $$c2023
000125926 5060_ $$aAccess copy available to the general public$$fUnrestricted
000125926 5203_ $$aStress is a critical factor in the development of mood and drug use disorders. The social defeat model is not appropriate for female rodents due to their low level of aggression. Therefore, a robust female model of social stress needs to be developed and validated. The aim of the present study was to unravel the long-lasting effects of vicarious social defeat (VSD) on the conditioned rewarding effects of cocaine and ethanol intake in female mice. Although VSD seems to be a good model for inducing behavioral and physiologic endophenotypes induced by stress, there are no studies to date that characterize the effect of VSD on cocaine or alcohol use. The results confirm that VSD females showed an increase in corticosterone levels after a vicarious experience while also displaying an increase in anxiety- and anhedonic-like behaviors. Three weeks after the last VSD, vicariously defeated female mice showed an increased developed preference for a non-effective dose of cocaine in the conditioned place preference (CPP) paradigm and showed an increase in ethanol intake. Our results suggest that female mice vicariously experience a state of distress through the social observation of others suffering from adverse events, confirming the use of VSD as a valid model to study the response to social stress in females. The fact that VSD in females induced a comparable behavioral phenotype to that observed in physically defeated males could indicate a relationship with the higher rate of psychopathologies observed in women. Notwithstanding, more studies are needed to dissect the neurobiological and behavioral peculiarities of the female response to social stress.
000125926 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII-RIAPAd/RD21-0009-0005$$9info:eu-repo/grantAgreement/ES/MICINN/PID2020-112672RB-100
000125926 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000125926 590__ $$a3.9$$b2023
000125926 592__ $$a0.962$$b2023
000125926 591__ $$aPHARMACOLOGY & PHARMACY$$b85 / 354 = 0.24$$c2023$$dQ1$$eT1
000125926 593__ $$aMedicine (miscellaneous)$$c2023$$dQ1
000125926 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b106 / 313 = 0.339$$c2023$$dQ2$$eT2
000125926 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2023$$dQ1
000125926 591__ $$aMEDICINE, RESEARCH & EXPERIMENTAL$$b65 / 189 = 0.344$$c2023$$dQ2$$eT2
000125926 594__ $$a5.2$$b2023
000125926 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000125926 700__ $$aArenas, María Carmen
000125926 700__ $$0(orcid)0000-0001-5990-1266$$aBlanco-Gandía, María Carmen$$uUniversidad de Zaragoza
000125926 700__ $$aManzanedo, Carmen
000125926 700__ $$aRodríguez-Arias, Marta
000125926 7102_ $$14009$$2735$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicolog.Evolut.Educac
000125926 773__ $$g11, 2 (2023), 502 [22 pp.]$$tBiomedicines$$x2227-9059
000125926 8564_ $$s11090377$$uhttps://zaguan.unizar.es/record/125926/files/texto_completo.pdf$$yVersión publicada
000125926 8564_ $$s2750725$$uhttps://zaguan.unizar.es/record/125926/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000125926 909CO $$ooai:zaguan.unizar.es:125926$$particulos$$pdriver
000125926 951__ $$a2024-11-22-12:06:25
000125926 980__ $$aARTICLE