000125940 001__ 125940
000125940 005__ 20230516110856.0
000125940 0247_ $$2doi$$a10.1111/adb.13072
000125940 0248_ $$2sideral$$a126844
000125940 037__ $$aART-2021-126844
000125940 041__ $$aeng
000125940 100__ $$aCostumero V.
000125940 245__ $$aDistance disintegration characterizes node-level topological dysfunctions in cocaine addiction
000125940 260__ $$c2021
000125940 5060_ $$aAccess copy available to the general public$$fUnrestricted
000125940 5203_ $$aPrevious investigations have used global graph theory measures in order to disentangle the complexity of the neural reorganizations occurring in cocaine use disorder (CUD). However, how these global topological alterations map into individual brain network areas remains unknown. In this study, we used resting state functional magnetic resonance imaging (fMRI) data to investigate node-level topological dysfunctions in CUD. The sample was composed of 32 individuals with CUD and 32 healthy controls, matched in age, years of education and intellectual functioning. Graph theory measures of optimal connectivity distance, node strength, nodal efficiency and clustering coefficient were estimated in each participant using voxel-wise functional connectivity connectomes. CUD individuals as compared with healthy controls showed higher optimal connectivity distances in ventral striatum, insula, cerebellum, temporal cortex, lateral orbitofrontal cortex, middle frontal cortex and left hippocampus. Furthermore, clinical measures quantifying severity of dependence were positively related with optimal connectivity distances in the right rolandic operculum and the right lateral orbitofrontal cortex, whereas length of abstinence was negatively associated with optimal connectivity distances in the right temporal pole and the left insula. Our results reveal a topological distancing of cognitive and affective related areas in addiction, suggesting an overall reduction in the communication capacity of these regions. © 2021 The Authors. Addiction Biology published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction.
000125940 536__ $$9info:eu-repo/grantAgreement/ES/MICINN/PID2019-105077RJ-I00$$9info:eu-repo/grantAgreement/ES/MSC/040-2011
000125940 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000125940 590__ $$a4.093$$b2021
000125940 591__ $$aSUBSTANCE ABUSE$$b11 / 21 = 0.524$$c2021$$dQ3$$eT2
000125940 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b156 / 297 = 0.525$$c2021$$dQ3$$eT2
000125940 592__ $$a1.185$$b2021
000125940 593__ $$aPharmacology$$c2021$$dQ1
000125940 593__ $$aMedicine (miscellaneous)$$c2021$$dQ1
000125940 594__ $$a7.4$$b2021
000125940 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000125940 700__ $$aRosell Negre P.
000125940 700__ $$0(orcid)0000-0002-8201-0469$$aBustamante J.C.$$uUniversidad de Zaragoza
000125940 700__ $$aFuentes-Claramonte P.
000125940 700__ $$0(orcid)0000-0002-0912-5139$$aAdrián-Ventura J.
000125940 700__ $$aPalomar-García M.Á.$$uUniversidad de Zaragoza
000125940 700__ $$aMiró-Padilla A.
000125940 700__ $$aLlopis J.J.
000125940 700__ $$aSepulcre J.
000125940 700__ $$aBarrós-Loscertales A.
000125940 7102_ $$14009$$2735$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicolog.Evolut.Educac
000125940 773__ $$g26, 6 (2021), e13072 [10 pp]$$pAddict. biol.$$tADDICTION BIOLOGY$$x1355-6215
000125940 8564_ $$s15303120$$uhttps://zaguan.unizar.es/record/125940/files/texto_completo.pdf$$yVersión publicada
000125940 8564_ $$s2180250$$uhttps://zaguan.unizar.es/record/125940/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000125940 909CO $$ooai:zaguan.unizar.es:125940$$particulos$$pdriver
000125940 951__ $$a2023-05-16-09:10:02
000125940 980__ $$aARTICLE