000125954 001__ 125954
000125954 005__ 20241125101134.0
000125954 0247_ $$2doi$$a10.3390/cimb45040217
000125954 0248_ $$2sideral$$a133229
000125954 037__ $$aART-2023-133229
000125954 041__ $$aeng
000125954 100__ $$0(orcid)0000-0002-2455-680X$$aLópez-Pingarrón, L.$$uUniversidad de Zaragoza
000125954 245__ $$aRole of oxidative stress on the etiology and pathophysiology of Amyotrophic Lateral Sclerosis (ALS) and its relation with the enteric nervous system
000125954 260__ $$c2023
000125954 5060_ $$aAccess copy available to the general public$$fUnrestricted
000125954 5203_ $$aAmyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting motor neurons in the spinal cord, cerebral cortex, and medulla oblongata. Most patients present a clinical phenotype of classic ALS—with predominant atrophy, muscle weakness, and fasciculations—and survival of 3 to 5 years following diagnosis. In the present review, we performed a literature search to provide an update on the etiology and pathophysiological mechanisms involved in ALS. There are two types of ALS: the familial form with genetic involvement, and the sporadic form with a multifactorial origin. ALS pathophysiology is characterized by involvement of multiple processes, including oxidative stress, glutamate excitotoxicity, and neuroinflammation. Moreover, it is proposed that conditioning risk factors affect ALS development, such as susceptibility to neurodegeneration in motor neurons, the intensity of performed physical activity, and intestinal dysbiosis with involvement of the enteric nervous system, which supports the existing theories of disease generation. To improve patients’ prognosis and survival, it is necessary to further deepen our understanding of the etiopathogenesis of ALS.
000125954 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000125954 590__ $$a2.8$$b2023
000125954 592__ $$a0.675$$b2023
000125954 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b184 / 313 = 0.588$$c2023$$dQ3$$eT2
000125954 593__ $$aMedicine (miscellaneous)$$c2023$$dQ2
000125954 593__ $$aMicrobiology$$c2023$$dQ2
000125954 593__ $$aMicrobiology (medical)$$c2023$$dQ2
000125954 593__ $$aMolecular Biology$$c2023$$dQ3
000125954 594__ $$a2.9$$b2023
000125954 655_4 $$ainfo:eu-repo/semantics/review$$vinfo:eu-repo/semantics/publishedVersion
000125954 700__ $$aAlmeida, H.
000125954 700__ $$0(orcid)0000-0002-6001-2738$$aSoria-Aznar, M.$$uUniversidad de Zaragoza
000125954 700__ $$0(orcid)0000-0002-2323-2053$$aReyes-Gonzales, M.C.$$uUniversidad de Zaragoza
000125954 700__ $$aTerrón, M.P.
000125954 700__ $$0(orcid)0000-0001-9507-6478$$aGarcía, J.J.$$uUniversidad de Zaragoza
000125954 7102_ $$11012$$2410$$aUniversidad de Zaragoza$$bDpto. Farmac.Fisiol.y Med.L.F.$$cÁrea Fisiología
000125954 773__ $$g45, 4 (2023), 3315-3332$$pCurr. issues mol. biol.$$tCURRENT ISSUES IN MOLECULAR BIOLOGY$$x1467-3037
000125954 8564_ $$s1377421$$uhttps://zaguan.unizar.es/record/125954/files/texto_completo.pdf$$yVersión publicada
000125954 8564_ $$s2702739$$uhttps://zaguan.unizar.es/record/125954/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000125954 909CO $$ooai:zaguan.unizar.es:125954$$particulos$$pdriver
000125954 951__ $$a2024-11-22-11:59:54
000125954 980__ $$aARTICLE