Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease

Young, W. J.; Reiner, A. P.; Stricker, B. H.; Repetto, L.; Mifsud, B.; Trompet, S.; Soliman, E. Z.; Goel, A.; Lambiase, P. D.; Wiggins, K. L.; Noordam, R.; Heckbert, S. R.; Ellervik, C.; van Duijvenboden, S.; Jukema, J. W.; Richmond, A.; Hayward, C.; van der Harst, P.; Campbell, A.; Pattaro, C.; Verweij, N.; Baldassari, A. R.; Stoll, M.; Soroush, N.; Lima-Costa, M. F.; Hansen, T.; Sinagra, G.; Sotoodehnia, N.; Olesen, M. S.; Deleuze, J. F.; Arking, D. E.; Pramstaller, P. P.; Isaksen, J. L.; Orini, M.; Whitsel, E. A.; Pina Concas, M.; Darbar, D.; Jackson, R. D.; Schotten, U.; Garnier, S.; Nursyifa, C.; Tinker, A.; Munroe, P. B.; Avery, C. L.; Tereshchenko, L. G.; Isaacs, A.; Kanters, J. K.; Kooperberg, C.; Macfarlane, P. W.; Ramirez, J.; Charron, P.; Warren, H. R.; Conen, D.; Mei, H.; Haessler, J.; Ribeiro, A. L. P.; Guo, X.; Fuchsberger, C.; De Luca, A.; Alonso, A.; van Duijn, C. M.; Villard, E.; Aeschbacher, S.; Santolalla, M. L.; Risch, L.; Sitlani, C. M.; Brody, J. A.; Navarro, P.; Rotter, J. I.; Ahmadizar, F.; Tarazona-Santos, E.; Correa, A.; Girotto, G.; Linneberg, A.; Shen, X.; Duong, T.; Wilson, J. F.; Morrison, A. C.; Thériault, S.; Harper, A. R.; Grace, C.; Yao, J.; Benjamins, J. W.; Lin, H. J.; Foco, L.; Trajanoska, K.; Porteous, D. J.; Watkins, H.; Padmanabhan, S.; Grarup, N.; Wilson, J. G.; Kors, J. A.; Psaty, B. M.; Mook-Kanamori, D. O.

doi:10.1038/s41467-023-36997-w

000125982 001__ 125982
000125982 005__ 20241125101137.0
000125982 0247_ $$2doi$$a10.1038/s41467-023-36997-w
000125982 0248_ $$2sideral$$a133586
000125982 037__ $$aART-2023-133586
000125982 041__ $$aeng
000125982 100__ $$aYoung, W. J.
000125982 245__ $$aGenetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease
000125982 260__ $$c2023
000125982 5060_ $$aAccess copy available to the general public$$fUnrestricted
000125982 5203_ $$aThe 3-dimensional spatial and 2-dimensional frontal QRS-T angles are measures derived from the vectorcardiogram. They are independent risk predictors for arrhythmia, but the underlying biology is unknown. Using multi-ancestry genome-wide association studies we identify 61 (58 previously unreported) loci for the spatial QRS-T angle (N = 118,780) and 11 for the frontal QRS-T angle (N = 159,715). Seven out of the 61 spatial QRS-T angle loci have not been reported for other electrocardiographic measures. Enrichments are observed in pathways related to cardiac and vascular development, muscle contraction, and hypertrophy. Pairwise genome-wide association studies with classical ECG traits identify shared genetic influences with PR interval and QRS duration. Phenome-wide scanning indicate associations with atrial fibrillation, atrioventricular block and arterial embolism and genetically determined QRS-T angle measures are associated with fascicular and bundle branch block (and also atrioventricular block for the frontal QRS-T angle). We identify potential biology involved in the QRS-T angle and their genetic relationships with cardiovascular traits and diseases, may inform future research and risk prediction.
000125982 536__ $$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 786833-GENESIS$$9info:eu-repo/grantAgreement/EC/H2020/786833/EU/GENetics and the Electrocardiogram for predicting Scd rISk/GENESIS$$9info:eu-repo/grantAgreement/EC/H2020/860974/EU/Personalized Therapies for Atrial Fibrillation. A Translational Approach/PersonalizeAF$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 860974-PersonalizeAF$$9info:eu-repo/grantAgreement/EC/H2020/965286/EU/Machine Learning Artificial Intelligence Early Detection Stroke Atrial Fibrillation/MAESTRIA$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 965286-MAESTRIA
000125982 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000125982 590__ $$a14.7$$b2023
000125982 592__ $$a4.887$$b2023
000125982 591__ $$aMULTIDISCIPLINARY SCIENCES$$b8 / 134 = 0.06$$c2023$$dQ1$$eT1
000125982 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2023$$dQ1
000125982 593__ $$aPhysics and Astronomy (miscellaneous)$$c2023$$dQ1
000125982 593__ $$aChemistry (miscellaneous)$$c2023$$dQ1
000125982 594__ $$a24.9$$b2023
000125982 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000125982 700__ $$aHaessler, J.
000125982 700__ $$aBenjamins, J. W.
000125982 700__ $$aRepetto, L.
000125982 700__ $$aYao, J.
000125982 700__ $$aIsaacs, A.
000125982 700__ $$aHarper, A. R.
000125982 700__ $$0(orcid)0000-0003-4130-5866$$aRamirez, J.$$uUniversidad de Zaragoza
000125982 700__ $$aGarnier, S.
000125982 700__ $$avan Duijvenboden, S.
000125982 700__ $$aBaldassari, A. R.
000125982 700__ $$aPina Concas, M.
000125982 700__ $$aDuong, T.
000125982 700__ $$aFoco, L.
000125982 700__ $$aIsaksen, J. L.
000125982 700__ $$aMei, H.
000125982 700__ $$aNoordam, R.
000125982 700__ $$aNursyifa, C.
000125982 700__ $$aRichmond, A.
000125982 700__ $$aSantolalla, M. L.
000125982 700__ $$aSitlani, C. M.
000125982 700__ $$aSoroush, N.
000125982 700__ $$aThériault, S.
000125982 700__ $$aTrompet, S.
000125982 700__ $$aAeschbacher, S.
000125982 700__ $$aAhmadizar, F.
000125982 700__ $$aAlonso, A.
000125982 700__ $$aBrody, J. A.
000125982 700__ $$aCampbell, A.
000125982 700__ $$aCorrea, A.
000125982 700__ $$aDarbar, D.
000125982 700__ $$aDe Luca, A.
000125982 700__ $$aDeleuze, J. F.
000125982 700__ $$aEllervik, C.
000125982 700__ $$aFuchsberger, C.
000125982 700__ $$aGoel, A.
000125982 700__ $$aGrace, C.
000125982 700__ $$aGuo, X.
000125982 700__ $$aHansen, T.
000125982 700__ $$aHeckbert, S. R.
000125982 700__ $$aJackson, R. D.
000125982 700__ $$aKors, J. A.
000125982 700__ $$aLima-Costa, M. F.
000125982 700__ $$aLinneberg, A.
000125982 700__ $$aMacfarlane, P. W.
000125982 700__ $$aMorrison, A. C.
000125982 700__ $$aNavarro, P.
000125982 700__ $$aPorteous, D. J.
000125982 700__ $$aPramstaller, P. P.
000125982 700__ $$aReiner, A. P.
000125982 700__ $$aRisch, L.
000125982 700__ $$aSchotten, U.
000125982 700__ $$aShen, X.
000125982 700__ $$aSinagra, G.
000125982 700__ $$aSoliman, E. Z.
000125982 700__ $$aStoll, M.
000125982 700__ $$aTarazona-Santos, E.
000125982 700__ $$aTinker, A.
000125982 700__ $$aTrajanoska, K.
000125982 700__ $$aVillard, E.
000125982 700__ $$aWarren, H. R.
000125982 700__ $$aWhitsel, E. A.
000125982 700__ $$aWiggins, K. L.
000125982 700__ $$aArking, D. E.
000125982 700__ $$aAvery, C. L.
000125982 700__ $$aConen, D.
000125982 700__ $$aGirotto, G.
000125982 700__ $$aGrarup, N.
000125982 700__ $$aHayward, C.
000125982 700__ $$aJukema, J. W.
000125982 700__ $$aMook-Kanamori, D. O.
000125982 700__ $$aOlesen, M. S.
000125982 700__ $$aPadmanabhan, S.
000125982 700__ $$aPsaty, B. M.
000125982 700__ $$aPattaro, C.
000125982 700__ $$aRibeiro, A. L. P.
000125982 700__ $$aRotter, J. I.
000125982 700__ $$aStricker, B. H.
000125982 700__ $$avan der Harst, P.
000125982 700__ $$avan Duijn, C. M.
000125982 700__ $$aVerweij, N.
000125982 700__ $$aWilson, J. G.
000125982 700__ $$aOrini, M.
000125982 700__ $$aCharron, P.
000125982 700__ $$aWatkins, H.
000125982 700__ $$aKooperberg, C.
000125982 700__ $$aLin, H. J.
000125982 700__ $$aWilson, J. F.
000125982 700__ $$aKanters, J. K.
000125982 700__ $$aSotoodehnia, N.
000125982 700__ $$aMifsud, B.
000125982 700__ $$aLambiase, P. D.
000125982 700__ $$aTereshchenko, L. G.
000125982 700__ $$aMunroe, P. B.
000125982 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000125982 773__ $$g14 (2023), 1411 [16 pp.]$$tNature communications$$x2041-1723
000125982 8564_ $$s3289767$$uhttps://zaguan.unizar.es/record/125982/files/texto_completo.pdf$$yVersión publicada
000125982 8564_ $$s2719772$$uhttps://zaguan.unizar.es/record/125982/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000125982 909CO $$ooai:zaguan.unizar.es:125982$$particulos$$pdriver
000125982 951__ $$a2024-11-22-12:01:23
000125982 980__ $$aARTICLE

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