000125989 001__ 125989 000125989 005__ 20241125101141.0 000125989 0247_ $$2doi$$a10.3389/fpsyg.2023.1008891 000125989 0248_ $$2sideral$$a133532 000125989 037__ $$aART-2023-133532 000125989 041__ $$aeng 000125989 100__ $$aGarcia-Toro, Mauro 000125989 245__ $$aMindfulness skills and experiential avoidance as therapeutic mechanisms for treatment-resistant depression through mindfulness-based cognitive therapy and lifestyle modification 000125989 260__ $$c2023 000125989 5060_ $$aAccess copy available to the general public$$fUnrestricted 000125989 5203_ $$aBackground/objective: The COVID-19 pandemic and consequent physical distancing has made it difficult to provide care for those with Treatment-Resistant Depression (TRD). As a secondary analysis of a clinical trial, the aim of this study was to explore potential mechanisms through which three online-delivered approaches, added to treatment as usual, improve depressive symptoms in TRD patients. Methods: The three approaches included (a) Minimal Lifestyle Intervention (MLI), (b) Mindfulness-Based Cognitive Therapy (MBCT), and (c) Lifestyle Modification Program (LMP). Sixty-six participants with TRD completed assessments pre-post intervention (mindfulness skills [FFMQ]; self-compassion [SCS]; and experiential avoidance [AAQ-II]) and pre-intervention to follow-up (depressive symptoms [BDI-II]). Data were analyzed using within-subjects regression models to test mediation. Results: Mindfulness skills mediated the effect of MBCT on depressive symptoms (ab = −4.69, 95% CI = −12.93 to−0.32), whereas the lack of experiential avoidance mediated the effect of LMP on depressive symptoms (ab = −3.22, 95% CI = −7.03 to−0.14). Conclusion: Strengthening mindfulness skills and decreasing experiential avoidance may promote recovery in patients with TRD, MBCT, and LMP have demonstrated that they may help increase mindfulness skills and decrease experiential avoidance, respectively. Future work will need to unpick the components of these interventions to help isolate active ingredients and increase optimization. 000125989 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FEDER/Another way to make Europe$$9info:eu-repo/grantAgreement/ES/MCIU/RTI2018-093590-B-I00 000125989 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000125989 590__ $$a2.6$$b2023 000125989 592__ $$a0.8$$b2023 000125989 591__ $$aPSYCHOLOGY, MULTIDISCIPLINARY$$b56 / 219 = 0.256$$c2023$$dQ2$$eT1 000125989 593__ $$aPsychology (miscellaneous)$$c2023$$dQ2 000125989 594__ $$a5.3$$b2023 000125989 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000125989 700__ $$0(orcid)0000-0003-2683-7346$$aAguilar-Latorre, Alejandra$$uUniversidad de Zaragoza 000125989 700__ $$aGarcia, Aurora 000125989 700__ $$aNavarro-Guzmán, Capilla 000125989 700__ $$aGervilla, Elena 000125989 700__ $$aSeguí, Andrea 000125989 700__ $$aGazquez, Francisco 000125989 700__ $$aMarino, Jose Antonio 000125989 700__ $$aGomez-Juanes, Rocío 000125989 700__ $$aSerrano-Ripoll, María J. 000125989 700__ $$0(orcid)0000-0001-6565-9699$$aOliván-Blázquez, Bárbara$$uUniversidad de Zaragoza 000125989 700__ $$0(orcid)0000-0002-3797-4218$$aGarcia-Campayo, Javier$$uUniversidad de Zaragoza 000125989 700__ $$aMaloney, Shannon 000125989 700__ $$aMontero-Marin, Jesús 000125989 7102_ $$14009$$2740$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicología Social 000125989 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Psiquiatría 000125989 7102_ $$14009$$2735$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicolog.Evolut.Educac 000125989 773__ $$g14 (2023), [9 pp.]$$pFront. psychol.$$tFrontiers in Psychology$$x1664-1078 000125989 8564_ $$s330309$$uhttps://zaguan.unizar.es/record/125989/files/texto_completo.pdf$$yVersión publicada 000125989 8564_ $$s2244189$$uhttps://zaguan.unizar.es/record/125989/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000125989 909CO $$ooai:zaguan.unizar.es:125989$$particulos$$pdriver 000125989 951__ $$a2024-11-22-12:02:41 000125989 980__ $$aARTICLE