000126229 001__ 126229
000126229 005__ 20241125101134.0
000126229 0247_ $$2doi$$a10.3390/cancers15071952
000126229 0248_ $$2sideral$$a133705
000126229 037__ $$aART-2023-133705
000126229 041__ $$aeng
000126229 100__ $$aHermoso-Durán, S.
000126229 245__ $$aBowel preparation for colonoscopy changes serum composition as detected by thermal liquid biopsy and fluorescence spectroscopy
000126229 260__ $$c2023
000126229 5060_ $$aAccess copy available to the general public$$fUnrestricted
000126229 5203_ $$a(1) Background: About 50% of prescribed colonoscopies report no pathological findings. A secondary screening test after fecal immunochemical test positivity (FIT+) would be required. Considering thermal liquid biopsy (TLB) as a potential secondary test, the aim of this work was to study possible interferences of colonoscopy bowel preparation on TLB outcome on a retrospective study; (2) Methods: Three groups were studied: 1/514 FIT(+) patients enrolled in a colorectal screening program (CN and CP with normal and pathological colonoscopy, respectively), with blood samples obtained just before colonoscopy and after bowel preparation; 2/55 patients from the CN group with blood sample redrawn after only standard 8–10 h fasting and no bowel preparation (CNR); and 3/55 blood donors from the biobank considered as a healthy control group; (3) Results: The results showed that from the 514 patients undergoing colonoscopy, 247 had CN and 267 had CP. TLB parameters in these two groups were similar but different from those of the blood donors. The resampled patients (with normal colonoscopy and no bowel preparation) had similar TLB parameters to those of the blood donors. TLB parameters together with fluorescence spectra and other serum indicators (albumin and C-reactive protein) confirmed the statistically significant differences between normal colonoscopy patients with and without bowel preparation; (4) Conclusions: Bowel preparation seemed to alter serum protein levels and altered TLB parameters (different from a healthy subject). The diagnostic capability of other liquid-biopsy-based methods might also be compromised. Blood extraction after bowel preparation for colonoscopy should be avoided.
000126229 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B25-17R$$9info:eu-repo/grantAgreement/ES/DGA/E45-17R$$9info:eu-repo/grantAgreement/ES/ISCIII-ERDF-ESF/PI18-00349-Investing in your future$$9info:eu-repo/grantAgreement/ES/ISCIII-ERDF-ESF/PI21-00394$$9info:eu-repo/grantAgreement/ES/ISCIII-FIS/FI19-00146$$9info:eu-repo/grantAgreement/ES/MICINN/AEI/PID2021-127296OB-I00
000126229 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000126229 590__ $$a4.5$$b2023
000126229 592__ $$a1.391$$b2023
000126229 591__ $$aONCOLOGY$$b78 / 322 = 0.242$$c2023$$dQ1$$eT1
000126229 593__ $$aOncology$$c2023$$dQ1
000126229 593__ $$aCancer Research$$c2023$$dQ2
000126229 594__ $$a8.0$$b2023
000126229 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000126229 700__ $$aDomper-Arnal, M. J.$$uUniversidad de Zaragoza
000126229 700__ $$aRoncales, P.
000126229 700__ $$0(orcid)0000-0002-1232-6310$$aVega, S.
000126229 700__ $$aSánchez-Gracia, Ó.
000126229 700__ $$0(orcid)0000-0003-0853-2880$$aOjeda, J. L.
000126229 700__ $$0(orcid)0000-0001-5932-2889$$aLanas, Á.$$uUniversidad de Zaragoza
000126229 700__ $$0(orcid)0000-0001-5702-4538$$aVelázquez-Campoy, A.$$uUniversidad de Zaragoza
000126229 700__ $$0(orcid)0000-0001-5664-1729$$aAbian, O.$$uUniversidad de Zaragoza
000126229 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000126229 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000126229 773__ $$g15, 7 (2023), 1952 [16 pp.]$$pCancers$$tCancers$$x2072-6694
000126229 8564_ $$s1679100$$uhttps://zaguan.unizar.es/record/126229/files/texto_completo.pdf$$yVersión publicada
000126229 8564_ $$s2828066$$uhttps://zaguan.unizar.es/record/126229/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000126229 909CO $$ooai:zaguan.unizar.es:126229$$particulos$$pdriver
000126229 951__ $$a2024-11-22-12:00:14
000126229 980__ $$aARTICLE