000126275 001__ 126275
000126275 005__ 20241125101149.0
000126275 0247_ $$2doi$$a10.1016/j.cattod.2023.114154
000126275 0248_ $$2sideral$$a133673
000126275 037__ $$aART-2023-133673
000126275 041__ $$aeng
000126275 100__ $$aMadrid, A.
000126275 245__ $$aNitrogen-doped carbon nanodots deposited on titania nanoparticles: unconventional near-infrared active photocatalysts for cancer therapy
000126275 260__ $$c2023
000126275 5060_ $$aAccess copy available to the general public$$fUnrestricted
000126275 5203_ $$aCancer represents a major public health issue and a primary cause of death for the mankind and the search for alternative cancer treatments that assist or alleviate the drawbacks of current cancer therapies remains imperative. Nanocatalytic medicine represents a new discipline that aims at exploiting the unique response of heterogeneous catalysts exposed to unconventional conditions such as those encountered in the tumor microenvironment (TME). Photo-triggered cancer therapies using light-activable catalytic materiales can stimulate and activate multiple biological processes and represent a very promising field of study. Herein, we evaluate the use of carbon nanodots with different composition (CNDs) retrieved by laser pyrolysis as potential near-infrared (NIR) photosensitizers able to activate P25 semiconductor nanostructured photocatalysts. We describe the enhanced photocatalytic response towards glucose conversion and reactive oxygen species (ROS) generation upon irradiation with NIR-LEDs when CNDs doped with heteroatoms were tested. The most active photocatalysts were evaluated in the presence of cancer cells and revealed a promising photodynamic effect under NIR irradiation. This work represents one of the scarce examples of a conventional inorganic photocatalyst containing TiO2 that is translated into a biomedical application with a successful outcome.
000126275 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII DTS21-00130$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 742684-CADENCE$$9info:eu-repo/grantAgreement/EC/H2020/742684/EU/Catalytic Dual-Function Devices Against Cancer/CADENCE$$9info:eu-repo/grantAgreement/EC/FP7/294094/EU/Synthesis and characterization of NANOstructured materials with LumInescent properties for diaGnostic and tHerapeuTic applications/NANOLIGHT$$9info:eu-repo/grantAgreement/ES/AEI/PID2020-114926RB-I00$$9info:eu-repo/grantAgreement/ES/ISCIII/PI19-01007
000126275 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000126275 590__ $$a5.2$$b2023
000126275 592__ $$a1.022$$b2023
000126275 591__ $$aCHEMISTRY, APPLIED$$b13 / 74 = 0.176$$c2023$$dQ1$$eT1
000126275 593__ $$aChemistry (miscellaneous)$$c2023$$dQ1
000126275 591__ $$aENGINEERING, CHEMICAL$$b35 / 170 = 0.206$$c2023$$dQ1$$eT1
000126275 593__ $$aCatalysis$$c2023$$dQ2
000126275 591__ $$aCHEMISTRY, PHYSICAL$$b60 / 178 = 0.337$$c2023$$dQ2$$eT2
000126275 594__ $$a11.5$$b2023
000126275 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000126275 700__ $$aMartín-Pardillos, A.$$uUniversidad de Zaragoza
000126275 700__ $$0(orcid)0000-0002-1791-0188$$aBonet-Aleta, J.$$uUniversidad de Zaragoza
000126275 700__ $$0(orcid)0000-0001-8762-5457$$aSancho-Albero, M.$$uUniversidad de Zaragoza
000126275 700__ $$0(orcid)0000-0001-7872-6301$$aMartinez, G.$$uUniversidad de Zaragoza
000126275 700__ $$0(orcid)0000-0002-1603-7305$$aCalzada-Funes, J.
000126275 700__ $$0(orcid)0000-0003-4160-9720$$aMartin-Duque, P.$$uUniversidad de Zaragoza
000126275 700__ $$0(orcid)0000-0002-8701-9745$$aSantamaria, J.$$uUniversidad de Zaragoza
000126275 700__ $$0(orcid)0000-0002-4546-4111$$aHueso, J. L.$$uUniversidad de Zaragoza
000126275 7102_ $$11013$$2275$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Estomatología
000126275 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000126275 773__ $$g419 (2023), 114154 [8 pp.]$$pCatal. today$$tCatalysis Today$$x0920-5861
000126275 8564_ $$s6369285$$uhttps://zaguan.unizar.es/record/126275/files/texto_completo.pdf$$yVersión publicada
000126275 8564_ $$s2467853$$uhttps://zaguan.unizar.es/record/126275/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000126275 909CO $$ooai:zaguan.unizar.es:126275$$particulos$$pdriver
000126275 951__ $$a2024-11-22-12:06:07
000126275 980__ $$aARTICLE