doi:10.1016/j.cattod.2023.114154engMadrid, A.Martín-Pardillos, A.Bonet-Aleta, J.Sancho-Albero, M.Martinez, G.Calzada-Funes, J.Martin-Duque, P.Santamaria, J.Hueso, J. L.Nitrogen-doped carbon nanodots deposited on titania nanoparticles: unconventional near-infrared active photocatalysts for cancer therapyART-2023-133673Cancer represents a major public health issue and a primary cause of death for the mankind and the search for alternative cancer treatments that assist or alleviate the drawbacks of current cancer therapies remains imperative. Nanocatalytic medicine represents a new discipline that aims at exploiting the unique response of heterogeneous catalysts exposed to unconventional conditions such as those encountered in the tumor microenvironment (TME). Photo-triggered cancer therapies using light-activable catalytic materiales can stimulate and activate multiple biological processes and represent a very promising field of study. Herein, we evaluate the use of carbon nanodots with different composition (CNDs) retrieved by laser pyrolysis as potential near-infrared (NIR) photosensitizers able to activate P25 semiconductor nanostructured photocatalysts. We describe the enhanced photocatalytic response towards glucose conversion and reactive oxygen species (ROS) generation upon irradiation with NIR-LEDs when CNDs doped with heteroatoms were tested. The most active photocatalysts were evaluated in the presence of cancer cells and revealed a promising photodynamic effect under NIR irradiation. This work represents one of the scarce examples of a conventional inorganic photocatalyst containing TiO2 that is translated into a biomedical application with a successful outcome.2023http://zaguan.unizar.es/record/12627510.1016/j.cattod.2023.114154http://zaguan.unizar.es/record/126275oai:zaguan.unizar.es:126275info:eu-repo/grantAgreement/ES/AEI/PID2020-114926RB-I00info:eu-repo/grantAgreement/EC/FP7/294094/EU/Synthesis and characterization of NANOstructured materials with LumInescent properties for diaGnostic and tHerapeuTic applications/NANOLIGHTinfo:eu-repo/grantAgreement/EC/H2020/742684/EU/Catalytic Dual-Function Devices Against Cancer/CADENCEThis project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 742684-CADENCEinfo:eu-repo/grantAgreement/ES/ISCIII DTS21-00130info:eu-repo/grantAgreement/ES/ISCIII/PI19-01007Catalysis Today 419 (2023), 114154 [8 pp.]by-nc-ndhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccess