126275 20241125101149.0 doi 10.1016/j.cattod.2023.114154 sideral 133673 ART-2023-133673 eng Madrid, A. Nitrogen-doped carbon nanodots deposited on titania nanoparticles: unconventional near-infrared active photocatalysts for cancer therapy 2023 Access copy available to the general public Unrestricted Cancer represents a major public health issue and a primary cause of death for the mankind and the search for alternative cancer treatments that assist or alleviate the drawbacks of current cancer therapies remains imperative. Nanocatalytic medicine represents a new discipline that aims at exploiting the unique response of heterogeneous catalysts exposed to unconventional conditions such as those encountered in the tumor microenvironment (TME). Photo-triggered cancer therapies using light-activable catalytic materiales can stimulate and activate multiple biological processes and represent a very promising field of study. Herein, we evaluate the use of carbon nanodots with different composition (CNDs) retrieved by laser pyrolysis as potential near-infrared (NIR) photosensitizers able to activate P25 semiconductor nanostructured photocatalysts. We describe the enhanced photocatalytic response towards glucose conversion and reactive oxygen species (ROS) generation upon irradiation with NIR-LEDs when CNDs doped with heteroatoms were tested. The most active photocatalysts were evaluated in the presence of cancer cells and revealed a promising photodynamic effect under NIR irradiation. This work represents one of the scarce examples of a conventional inorganic photocatalyst containing TiO2 that is translated into a biomedical application with a successful outcome. info:eu-repo/grantAgreement/ES/AEI/PID2020-114926RB-I00 info:eu-repo/grantAgreement/EC/FP7/294094/EU/Synthesis and characterization of NANOstructured materials with LumInescent properties for diaGnostic and tHerapeuTic applications/NANOLIGHT info:eu-repo/grantAgreement/EC/H2020/742684/EU/Catalytic Dual-Function Devices Against Cancer/CADENCE This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 742684-CADENCE info:eu-repo/grantAgreement/ES/ISCIII DTS21-00130 info:eu-repo/grantAgreement/ES/ISCIII/PI19-01007 info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 5.2 2023 CHEMISTRY, APPLIED 13 / 74 = 0.176 2023 Q1 T1 ENGINEERING, CHEMICAL 35 / 170 = 0.206 2023 Q1 T1 CHEMISTRY, PHYSICAL 60 / 178 = 0.337 2023 Q2 T2 1.022 2023 Chemistry (miscellaneous) 2023 Q1 Catalysis 2023 Q2 11.5 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Martín-Pardillos, A. Universidad de Zaragoza Bonet-Aleta, J. Universidad de Zaragoza (orcid)0000-0002-1791-0188 Sancho-Albero, M. Universidad de Zaragoza (orcid)0000-0001-8762-5457 Martinez, G. Universidad de Zaragoza (orcid)0000-0001-7872-6301 Calzada-Funes, J. (orcid)0000-0002-1603-7305 Martin-Duque, P. Universidad de Zaragoza (orcid)0000-0003-4160-9720 Santamaria, J. Universidad de Zaragoza (orcid)0000-0002-8701-9745 Hueso, J. L. Universidad de Zaragoza (orcid)0000-0002-4546-4111 1013 275 Universidad de Zaragoza Dpto. Cirugía Área Estomatología 5005 555 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Ingeniería Química 419 (2023), 114154 [8 pp.] Catal. today Catalysis Today 0920-5861 6369285 http://zaguan.unizar.es/record/126275/files/texto_completo.pdf Versión publicada 2467853 http://zaguan.unizar.es/record/126275/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:126275 articulos driver 2024-11-22-12:06:07 ARTICLE