Repositorio Institucional de Documentos

000126342 001__ 126342
000126342 005__ 20241125101138.0
000126342 0247_ $$2doi$$a10.1007/s11259-023-10087-0
000126342 0248_ $$2sideral$$a133807
000126342 037__ $$aART-2023-133807
000126342 041__ $$aeng
000126342 100__ $$0(orcid)0000-0001-6209-4282$$aVillanueva-Saz, Sergio$$uUniversidad de Zaragoza
000126342 245__ $$aThe dynamics of neutralizing antibodies against SARS-CoV-2 in cats naturally exposed to virus reveals an increase in antibody activity after re-infection
000126342 260__ $$c2023
000126342 5060_ $$aAccess copy available to the general public$$fUnrestricted
000126342 5203_ $$aSevere Acute Respiratory Syndrome Coronavirus 2 is the causative agent of Coronavirus Disease 2019 in humans. To date, little is known about the persistence of antibodies against SARS-CoV-2 in animals under natural conditions, in particular susceptible pets such as cat. This study reports the detection and monitoring of the humoral response against SARS-CoV-2 including the detection of immunoglobulins G specific for receptor binding domain of SARS-CoV-2 spike protein by an enzyme-linked immunosorbent assay and neutralizing antibodies by virus neutralization assay. Results showed that these antibodies last longer than 16 months in two naturally apparently healthy infected cats with the absence of clinicopathological findings during the follow-up. Moreover, re-infection is also possible with an important increase in virus neutralization test titers in both animals with no evident systemic signs found during each physical examination and with values of hematologic and biochemical parameters inside the normal reference intervals. Our results confirm a slow but progressive decrease of the kinetics and immunity of neutralizing antibodies in cats after the infection. Furthermore, similar to humans SARS-CoV-2 reinfection can stimulate an increase of the neutralizing antibodies determined by these two serological techniques in domestic cats.
000126342 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000126342 590__ $$a1.8$$b2023
000126342 592__ $$a0.483$$b2023
000126342 591__ $$aVETERINARY SCIENCES$$b53 / 167 = 0.317$$c2023$$dQ2$$eT1
000126342 593__ $$aVeterinary (miscellaneous)$$c2023$$dQ2
000126342 593__ $$aMedicine (miscellaneous)$$c2023$$dQ3
000126342 594__ $$a2.5$$b2023
000126342 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000126342 700__ $$0(orcid)0000-0002-9071-1919$$aMartínez, Marivi
000126342 700__ $$aRueda, Pablo
000126342 700__ $$aBolea, Sara
000126342 700__ $$0(orcid)0000-0003-2555-8425$$aPérez, María Dolores$$uUniversidad de Zaragoza
000126342 700__ $$0(orcid)0000-0003-2957-1379$$aVerde, Maite$$uUniversidad de Zaragoza
000126342 700__ $$aYzuel, Andrés
000126342 700__ $$0(orcid)0000-0002-3122-9401$$aHurtado-Guerrero, Ramón
000126342 700__ $$0(orcid)0000-0003-0154-0730$$aPardo, Julián$$uUniversidad de Zaragoza
000126342 700__ $$0(orcid)0000-0002-1861-5981$$aSantiago, Llipsy
000126342 700__ $$0(orcid)0000-0002-2557-4890$$aFernández, Antonio$$uUniversidad de Zaragoza
000126342 700__ $$0(orcid)0000-0002-9730-2210$$aArias, Maykel
000126342 7102_ $$11011$$2566$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Inmunología
000126342 7102_ $$11009$$2617$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Medicina y Cirugía Animal
000126342 7102_ $$12008$$2780$$aUniversidad de Zaragoza$$bDpto. Produc.Animal Cienc.Ali.$$cÁrea Tecnología de Alimentos
000126342 773__ $$g47 (2023), 2179–2184$$pVet. res. commun.$$tVeterinary Research Communications$$x0165-7380
000126342 8564_ $$s773356$$uhttps://zaguan.unizar.es/record/126342/files/texto_completo.pdf$$yVersión publicada
000126342 8564_ $$s2083915$$uhttps://zaguan.unizar.es/record/126342/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000126342 909CO $$ooai:zaguan.unizar.es:126342$$particulos$$pdriver
000126342 951__ $$a2024-11-22-12:01:35
000126342 980__ $$aARTICLE

El sistema ha encontrado un error mientras gestionaba su petición.

Los administradores del sistema han sido avisados.

En caso de duda, póngase en contacto con deposita@unizar.es