000126350 001__ 126350
000126350 005__ 20241125101140.0
000126350 0247_ $$2doi$$a10.3390/molecules28104228
000126350 0248_ $$2sideral$$a133768
000126350 037__ $$aART-2023-133768
000126350 041__ $$aeng
000126350 100__ $$0(orcid)0000-0002-5904-8506$$aBueno, Mónica$$uUniversidad de Zaragoza
000126350 245__ $$aOptimization and Validation of a Method to Determine Enolones and Vanillin Derivatives in Wines—Occurrence in Spanish Red Wines and Mistelles
000126350 260__ $$c2023
000126350 5060_ $$aAccess copy available to the general public$$fUnrestricted
000126350 5203_ $$aUnderstanding the chemical nature of wine aroma demands accurate quantitative determinations of different odor-active compounds. Quantitative determinations of enolones (maltol, furaneol, homofuraneol, and sotolon) and vanillin derivatives (vanillin, methyl vanillate, ethyl vanillate, and acetovanillone) at low concentrations are complicated due to their high polarity. For this reason, this paper presents an improved and automated version for the accurate measure of these common trace wine polar compounds (enolones and vanillin derivatives). As a result, a faster and more user-friendly method with a reduction of organic solvents and resins was developed and validated. The optimization of some stages of the solid phase extraction (SPE) process, such as washing with an aqueous solution containing 1% NaHCO3 at pH 8, led to cleaner extracts and solved interference problems. Due to the polarity of these type of compounds, an optimization of the large volume injection was also carried out. Finally, a programmable temperature vaporization (PTV) quartz glass inlet liner without wool was used. The injector temperature was raised to 300 °C in addition to applying a pressure pulse of 180 kPa for 4 min. Matrix effects were solved by the use of adequate internal standards, such as ethyl maltol and 3′,4′-(methylenedioxy)acetophenone. Method figures of merit were highly satisfactory: good linearity (r2 > 0.98), precision (relative standard deviation, RSD < 10%), high recovery (RSD > 89%), and low detection limits (<0.7 μg/L). Enolones and vanillin derivatives are associated with wine aging. For this reason, the methodology was successfully applied to the quantification of these compounds in 16 Spanish red wines and 12 mistelles. Odor activity values (OAV) indicate that furaneol should be considered an aroma impact odorant in red wines and mistelles (OAV > 1) while homofuraneol and sotolon could also produce changes in their aroma perceptions (0.1 < OAV < 1).
000126350 536__ $$9info:eu-repo/grantAgreement/ES/DGA/T29$$9info:eu-repo/grantAgreement/ES/MCIU/IJC-2018-037830-I
000126350 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000126350 590__ $$a4.2$$b2023
000126350 592__ $$a0.744$$b2023
000126350 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b77 / 231 = 0.333$$c2023$$dQ2$$eT2
000126350 593__ $$aAnalytical Chemistry$$c2023$$dQ1
000126350 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b88 / 313 = 0.281$$c2023$$dQ2$$eT1
000126350 593__ $$aPharmaceutical Science$$c2023$$dQ1
000126350 593__ $$aChemistry (miscellaneous)$$c2023$$dQ1
000126350 593__ $$aOrganic Chemistry$$c2023$$dQ2
000126350 593__ $$aPhysical and Theoretical Chemistry$$c2023$$dQ2
000126350 593__ $$aDrug Discovery$$c2023$$dQ2
000126350 593__ $$aMedicine (miscellaneous)$$c2023$$dQ2
000126350 593__ $$aMolecular Medicine$$c2023$$dQ3
000126350 594__ $$a7.4$$b2023
000126350 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000126350 700__ $$aZapata, Julián
000126350 700__ $$0(orcid)0000-0003-4507-1323$$aCulleré, Laura
000126350 700__ $$0(orcid)0000-0003-4345-3950$$aFranco-Luesma, Ernesto
000126350 700__ $$0(orcid)0000-0002-4093-900X$$ade-la-Fuente-Blanco, Arancha$$uUniversidad de Zaragoza
000126350 700__ $$0(orcid)0000-0002-4353-2483$$aFerreira, Vicente$$uUniversidad de Zaragoza
000126350 7102_ $$12009$$2750$$aUniversidad de Zaragoza$$bDpto. Química Analítica$$cÁrea Química Analítica
000126350 773__ $$g28, 10 (2023), 4228 [16 pp.]$$pMolecules (Basel, Online)$$tMolecules$$x1420-3049
000126350 8564_ $$s4081195$$uhttps://zaguan.unizar.es/record/126350/files/texto_completo.pdf$$yVersión publicada
000126350 8564_ $$s2698296$$uhttps://zaguan.unizar.es/record/126350/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000126350 909CO $$ooai:zaguan.unizar.es:126350$$particulos$$pdriver
000126350 951__ $$a2024-11-22-12:02:20
000126350 980__ $$aARTICLE