000126381 001__ 126381
000126381 005__ 20241125101123.0
000126381 0247_ $$2doi$$a10.1016/j.molmet.2023.101728
000126381 0248_ $$2sideral$$a133869
000126381 037__ $$aART-2023-133869
000126381 041__ $$aeng
000126381 100__ $$aMocciaro, G.
000126381 245__ $$aNon-alcoholic fatty liver disease is characterised by a reduced polyunsaturated fatty acid transport via free fatty acids and high-density lipoproteins (HDL)
000126381 260__ $$c2023
000126381 5060_ $$aAccess copy available to the general public$$fUnrestricted
000126381 5203_ $$aBackground and objectives: Non-alcoholic fatty liver disease (NAFLD) develops due to impaired hepatic lipid fluxes and is a risk factor for chronic liver disease and atherosclerosis. Lipidomic studies consistently reported characteristic hepatic/VLDL “lipid signatures” in NAFLD; whole plasma traits are more debated. Surprisingly, the HDL lipid composition by mass spectrometry has not been characterised across the NAFLD spectrum, despite HDL being a possible source of hepatic lipids delivered from peripheral tissues alongside free fatty acids (FFA). This study characterises the HDL lipidomic signature in NAFLD, and its correlation with metabolic and liver disease markers. Methods: We used liquid chromatography-mass spectrometry to determine the whole serum and HDL lipidomic profile in 89 biopsy-proven NAFLD patients and 20 sex and age-matched controls. Results: In the whole serum of NAFLD versus controls, we report a depletion in polyunsaturated (PUFA) phospholipids (PL) and FFA; with PUFA PL being also lower in HDL, and negatively correlated with BMI, insulin resistance, triglycerides, and hepatocyte ballooning. In the HDL of the NAFLD group we also describe higher saturated ceramides, which positively correlate with insulin resistance and transaminases. Conclusion: NAFLD features lower serum lipid species containing polyunsaturated fatty acids; the most affected lipid fractions are FFA and (HDL) phospholipids; our data suggest a possible defect in the transfer of PUFA from peripheral tissues to the liver in NAFLD. Mechanistic studies are required to explore the biological implications of our findings addressing if HDL composition can influence liver metabolism and damage, thus contributing to NAFLD pathophysiology.
000126381 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000126381 590__ $$a7.0$$b2023
000126381 592__ $$a3.034$$b2023
000126381 591__ $$aENDOCRINOLOGY & METABOLISM$$b16 / 186 = 0.086$$c2023$$dQ1$$eT1
000126381 593__ $$aMolecular Biology$$c2023$$dQ1
000126381 593__ $$aCell Biology$$c2023$$dQ1
000126381 594__ $$a14.5$$b2023
000126381 655_4 $$ainfo:eu-repo/semantics/conferenceObject$$vinfo:eu-repo/semantics/publishedVersion
000126381 700__ $$aAllison, M.
000126381 700__ $$aJenkins, B.
000126381 700__ $$aAzzu, V.
000126381 700__ $$aHuang-Doran, I.
000126381 700__ $$0(orcid)0000-0002-4665-9674$$aHerrera-Marcos, L. V.$$uUniversidad de Zaragoza
000126381 700__ $$aHall, Z.
000126381 700__ $$aMurgia, A.
000126381 700__ $$aSusan, D.
000126381 700__ $$aFrontini, M.
000126381 700__ $$aVidal-Puig, A.
000126381 700__ $$aKoulman, A.
000126381 700__ $$aGriffin, J. L.
000126381 700__ $$aVacca, M.
000126381 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000126381 773__ $$g73 (2023), 101728 [11 pp.]$$pMolecular metabolism.$$tMolecular Metabolism$$x2212-8778
000126381 8564_ $$s1669425$$uhttps://zaguan.unizar.es/record/126381/files/texto_completo.pdf$$yVersión publicada
000126381 8564_ $$s2586623$$uhttps://zaguan.unizar.es/record/126381/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000126381 909CO $$ooai:zaguan.unizar.es:126381$$particulos$$pdriver
000126381 951__ $$a2024-11-22-11:57:03
000126381 980__ $$aARTICLE