126395 20240319081011.0 doi 10.1111/jam.15699 sideral 130128 ART-2022-130128 eng Serrano, Laura Assessment of humoral immune response to two mRNA SARS-CoV-2 vaccines (Moderna and Pfizer) in healthcare workers fully vaccinated with and without a history of previous infection 2022 Access copy available to the general public Unrestricted Aims: Presence of anti-S1 region of SARS-CoV-2 spike protein was analysed, at two and eight months, in 477 immunocompetent healthcare workers in Zaragoza, Spain, vaccinated with mRNA-1273 (Moderna) or BNT162b2 (Pfizer). Methods and results: Antibody analysis was performed with Alinity i System (Abbott). At 2 months, 100% of vaccinated had anti-S1 IgG (mean = 13, 285 AU ml-1). This value was significantly higher with Moderna (18, 192 AU ml-1) than with Pfizer (10, 441 AU ml-1). The mean value of anti-S1 IgG after vaccination was significantly higher in patients with than without previous infection (18, 539 vs. 7919 AU ml-1); in both groups was significantly higher with Moderna than with Pfizer (21, 881 vs. 15, 733 AU ml-1 and 11, 949 vs. 6387 AU ml-1), respectively. At 8 months, 100% of patients were IgG positive, with higher levels with Moderna than with Pfizer. Nevertheless, in ensemble of cases, a mean decrease of antibody levels of 11, 025 AU ml-1 was observed. Conclusion: At 2 and 8 months after vaccination, IgG response persists with both vaccines but with important decrease which suggests the need for revaccination. Significance and impact of study: The study contributes to know the immune status after vaccination with two of more used anti-SARS-CoV-2 vaccines. This knowledge is important for establishing the best vaccination strategy. © 2022 The Authors. Journal of Applied Microbiology published by John Wiley & Sons Ltd on behalf of Society for Applied Microbiology. info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.0 2022 MICROBIOLOGY 58 / 135 = 0.43 2022 Q2 T2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY 55 / 158 = 0.348 2022 Q2 T2 0.774 2022 Applied Microbiology and Biotechnology 2022 Q2 Medicine (miscellaneous) 2022 Q2 Biotechnology 2022 Q2 6.7 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Algarate, Sonia Universidad de Zaragoza (orcid)0000-0002-0036-6630 Herrero-Cortina, Beatriz Bueno, Jessica González-Barriga, Maria T. Ducons, Maria Montero-Marco, Jesica Acha, Beatriz Taboada, Ana Sanz-Burillo, Pilar Yuste, Cristina Benito, Rafael Universidad de Zaragoza (orcid)0000-0001-5134-1006 RIPOVAC, Study Group 1011 630 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Microbiología 133, 3 (2022), 1969-1974 J. appl. microbiol. Journal of Applied Microbiology 1364-5072 341219 http://zaguan.unizar.es/record/126395/files/texto_completo.pdf Versión publicada 2522000 http://zaguan.unizar.es/record/126395/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:126395 articulos driver 2024-03-18-15:08:25 ARTICLE