000126399 001__ 126399
000126399 005__ 20240124152522.0
000126399 0247_ $$2doi$$a10.1109/DCIS55711.2022.9970060
000126399 0248_ $$2sideral$$a132436
000126399 037__ $$aART-2022-132436
000126399 041__ $$aeng
000126399 100__ $$0(orcid)0000-0003-4361-6676$$aVelarte, A.$$uUniversidad de Zaragoza
000126399 245__ $$aImproving signal stability in a multi-electrode array (MEA) system for cardiac biopsies
000126399 260__ $$c2022
000126399 5060_ $$aAccess copy available to the general public$$fUnrestricted
000126399 5203_ $$aThis work evaluates the performance of a microelectrode array (MEA) to be used in a specific platform dedicated for measuring field potentials of small human cardiac samples. A test bench has been developed to characterize the electrodes by measuring their impedance as well as to modify their characteristic curve using a replatinization process, where black platinum is deposited on the indicated areas of the MEA flex-pcb. This set-up consists of the array of microelectrodes made of gold, together with its corresponding electronic adapter board, a potentiostat and an electrochemical interface. Phosphate buffered saline (PBS), which is commonly considered for this type of analysis, has been used for impedance characterization. Initially, the impedance presents a highly variable behavior at different frequencies as well as between the different channels of the array. Once the platinization process has been carried out, the impedance in all the recording channels is very similar and has decreased over a large part of the frequency range under study. A complete electrical model of the electrodes has been proposed and analyzed, achieving better results by including the mathematical constant phase element (CPE) associated with capacitive behavior (model fitting error < 2%). Finally, the characterization of the different noise contributions has been carried out. Based on the obtained results, it can be concluded that the evaluated system allows the recording of field potential signals from small human cardiac tissues.
000126399 536__ $$9info:eu-repo/grantAgreement/ES/AEI/PID2019-105674RB-I00$$9info:eu-repo/grantAgreement/ES/DGA-FSE/T39-20R$$9info:eu-repo/grantAgreement/ES/DGA/LMP94_21$$9info:eu-repo/grantAgreement/EC/H2020/638284/EU/Is your heart aging well? A systems biology approach to characterize cardiac aging from the cell to the body surface/MODELAGE$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 638284-MODELAGE
000126399 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000126399 655_4 $$ainfo:eu-repo/semantics/conferenceObject$$vinfo:eu-repo/semantics/acceptedVersion
000126399 700__ $$0(orcid)0000-0003-1403-1505$$aOtín, A.$$uUniversidad de Zaragoza
000126399 700__ $$0(orcid)0000-0002-1960-407X$$aPueyo, E.$$uUniversidad de Zaragoza
000126399 700__ $$aGuimera, A.
000126399 700__ $$aVilla, R.
000126399 7102_ $$15008$$2785$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Tecnología Electrónica
000126399 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000126399 773__ $$g37th (2022), [6 pp.]$$pProceedings (Conf. Des. Circuits Integr. Syst.)$$tProceedings (Conference on Design of Circuits and Integrated Systems)$$x2471-6170
000126399 8564_ $$s1338148$$uhttps://zaguan.unizar.es/record/126399/files/texto_completo.pdf$$yPostprint
000126399 8564_ $$s3322486$$uhttps://zaguan.unizar.es/record/126399/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000126399 909CO $$ooai:zaguan.unizar.es:126399$$particulos$$pdriver
000126399 951__ $$a2024-01-24-15:20:45
000126399 980__ $$aARTICLE