126405 20241125101134.0 doi 10.3390/cells12091338 sideral 133889 ART-2023-133889 eng Mendoza, Gracia (orcid)0000-0003-2293-363X The E1a adenoviral gene upregulates the yamanaka factors to induce partial cellular reprogramming 2023 Access copy available to the general public Unrestricted The induction of pluripotency by enforced expression of different sets of genes in somatic cells has been achieved with reprogramming technologies first described by Yamanaka’s group. Methodologies for generating induced pluripotent stem cells are as varied as the combinations of genes used. It has previously been reported that the adenoviral E1a gene can induce the expression of two of the Yamanaka factors (c-Myc and Oct-4) and epigenetic changes. Here, we demonstrate that the E1a-12S over-expression is sufficient to induce pluripotent-like characteristics closely to epiblast stem cells in mouse embryonic fibroblasts through the activation of the pluripotency gene regulatory network. These findings provide not only empirical evidence that the expression of one single factor is sufficient for partial reprogramming but also a potential mechanistic explanation for how viral infection could lead to neoplasia if they are surrounded by the appropriate environment or the right medium, as happens with the tumorogenic niche. info:eu-repo/grantAgreement/ES/DGA/B054-12 info:eu-repo/grantAgreement/ES/ISCIII DTS21-00130 info:eu-repo/grantAgreement/ES/ISCIII/PI19-01007 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 5.1 2023 CELL BIOLOGY 63 / 205 = 0.307 2023 Q2 T1 1.547 2023 Biochemistry, Genetics and Molecular Biology (miscellaneous) 2023 Q1 9.9 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion González-Pastor, Rebeca (orcid)0000-0002-5630-6645 Sánchez, Juan Miguel Arce-Cerezo, Altamira Quintanilla, Miguel Moreno-Bueno, Gema Pujol, Anna Belmar-López, Carolina de Martino, Alba Riu, Efrén Rodriguez, Tristan A. Martin-Duque, Pilar Universidad de Zaragoza (orcid)0000-0003-4160-9720 1013 275 Universidad de Zaragoza Dpto. Cirugía Área Estomatología 12, 9 (2023), 1338 [17 pp.] Cells Cells 2073-4409 3080341 http://zaguan.unizar.es/record/126405/files/texto_completo.pdf Versión publicada 2654036 http://zaguan.unizar.es/record/126405/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:126405 articulos driver 2024-11-22-11:59:57 ARTICLE