000126425 001__ 126425
000126425 005__ 20241125101138.0
000126425 0247_ $$2doi$$a10.3389/fphys.2023.1145818
000126425 0248_ $$2sideral$$a133895
000126425 037__ $$aART-2023-133895
000126425 041__ $$aeng
000126425 100__ $$0(orcid)0000-0002-1297-0691$$aKontaxis, Spyridon$$uUniversidad de Zaragoza
000126425 245__ $$aAutonomic response to walk tests is useful for assessing outcome measures in people with multiple sclerosis
000126425 260__ $$c2023
000126425 5060_ $$aAccess copy available to the general public$$fUnrestricted
000126425 5203_ $$aObjective: The aim of this study was to evaluate the association between changes in the autonomic control of cardiorespiratory system induced by walk tests and outcome measures in people with Multiple Sclerosis (pwMS).Methods: Electrocardiogram (ECG) recordings of 148 people with Relapsing-Remitting MS (RRMS) and 58 with Secondary Progressive MS (SPMS) were acquired using a wearable device before, during, and after walk test performance from a total of 386 periodical clinical visits. A subset of 90 participants repeated a walk test at home. Various MS-related symptoms, including fatigue, disability, and walking capacity were evaluated at each clinical visit, while heart rate variability (HRV) and ECG-derived respiration (EDR) were analyzed to assess autonomic nervous system (ANS) function. Statistical tests were conducted to assess differences in ANS control between pwMS grouped based on the phenotype or the severity of MS-related symptoms. Furthermore, correlation coefficients (r) were calculated to assess the association between the most significant ANS parameters and MS-outcome measures.Results: People with SPMS, compared to RRMS, reached higher mean heart rate (HRM) values during walk test, and larger sympathovagal balance after test performance. Furthermore, pwMS who were able to adjust their HRM and ventilatory values, such as respiratory rate and standard deviation of the ECG-derived respiration, were associated with better clinical outcomes. Correlation analyses showed weak associations between ANS parameters and clinical outcomes when the Multiple Sclerosis phenotype is not taken into account. Blunted autonomic response, in particular HRM reactivity, was related with worse walking capacity, yielding r = 0.36 r = 0.29 (RRMS) and r > 0.5 (SPMS). A positive strong correlation r > 0.7 r > 0.65 between cardiorespiratory parameters derived at hospital and at home was also found.Conclusion: Autonomic function, as measured by HRV, differs according to MS phenotype. Autonomic response to walk tests may be useful for assessing clinical outcomes, mainly in the progressive stage of MS. Participants with larger changes in HRM are able to walk longer distance, while reduced ventilatory function during and after walk test performance is associated with higher fatigue and disability severity scores. Monitoring of disorder severity could also be feasible using ECG-derived cardiac and respiratory parameters recorded with a wearable device at home.
000126425 536__ $$9info:eu-repo/grantAgreement/EC/H2020/115902/EU/Remote Assessment of Disease and Relapse in Central Nervous System Disorders/RADAR-CNS$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 115902-RADAR-CNS$$9info:eu-repo/grantAgreement/EUR/MICINN/TED2021-131106B-I00
000126425 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000126425 590__ $$a3.2$$b2023
000126425 592__ $$a1.006$$b2023
000126425 591__ $$aPHYSIOLOGY$$b24 / 85 = 0.282$$c2023$$dQ2$$eT1
000126425 593__ $$aPhysiology (medical)$$c2023$$dQ2
000126425 593__ $$aPhysiology$$c2023$$dQ2
000126425 594__ $$a6.5$$b2023
000126425 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000126425 700__ $$aLaporta, Estela
000126425 700__ $$aGarcia, Esther
000126425 700__ $$aGuerrero, Ana Isabel
000126425 700__ $$aZabalza, Ana
000126425 700__ $$aMatteo, Martinis
000126425 700__ $$aLucia, Roselli
000126425 700__ $$aSimblett, Sara
000126425 700__ $$aWeyer, Janice
000126425 700__ $$aHotopf, Matthew
000126425 700__ $$aNarayan, Vaibhav A.
000126425 700__ $$aRashid, Zulqarnain
000126425 700__ $$aFolarin, Amos A.
000126425 700__ $$aDobson, Richard J. B.
000126425 700__ $$aBuron, Mathias Due
000126425 700__ $$aLeocani, Letizia
000126425 700__ $$aCummins, Nicholas
000126425 700__ $$aVairavan, Srinivasan
000126425 700__ $$aCosta, Gloria Dalla
000126425 700__ $$aMagyari, Melinda
000126425 700__ $$aSørensen, Per Soelberg
000126425 700__ $$aNos, Carlos
000126425 700__ $$0(orcid)0000-0003-1272-0550$$aBailón, Raquel$$uUniversidad de Zaragoza
000126425 700__ $$aComi, Giancarlo
000126425 700__ $$athe RADAR-CNS Consortium
000126425 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000126425 773__ $$g14 (2023), 1145818 [13 pp.]$$pFront. physiol.$$tFrontiers in physiology$$x1664-042X
000126425 8564_ $$s539754$$uhttps://zaguan.unizar.es/record/126425/files/texto_completo.pdf$$yVersión publicada
000126425 8564_ $$s2582818$$uhttps://zaguan.unizar.es/record/126425/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000126425 909CO $$ooai:zaguan.unizar.es:126425$$particulos$$pdriver
000126425 951__ $$a2024-11-22-12:01:46
000126425 980__ $$aARTICLE