126425 20241125101138.0 doi 10.3389/fphys.2023.1145818 sideral 133895 ART-2023-133895 eng Kontaxis, Spyridon Universidad de Zaragoza (orcid)0000-0002-1297-0691 Autonomic response to walk tests is useful for assessing outcome measures in people with multiple sclerosis 2023 Access copy available to the general public Unrestricted Objective: The aim of this study was to evaluate the association between changes in the autonomic control of cardiorespiratory system induced by walk tests and outcome measures in people with Multiple Sclerosis (pwMS).Methods: Electrocardiogram (ECG) recordings of 148 people with Relapsing-Remitting MS (RRMS) and 58 with Secondary Progressive MS (SPMS) were acquired using a wearable device before, during, and after walk test performance from a total of 386 periodical clinical visits. A subset of 90 participants repeated a walk test at home. Various MS-related symptoms, including fatigue, disability, and walking capacity were evaluated at each clinical visit, while heart rate variability (HRV) and ECG-derived respiration (EDR) were analyzed to assess autonomic nervous system (ANS) function. Statistical tests were conducted to assess differences in ANS control between pwMS grouped based on the phenotype or the severity of MS-related symptoms. Furthermore, correlation coefficients (r) were calculated to assess the association between the most significant ANS parameters and MS-outcome measures.Results: People with SPMS, compared to RRMS, reached higher mean heart rate (HRM) values during walk test, and larger sympathovagal balance after test performance. Furthermore, pwMS who were able to adjust their HRM and ventilatory values, such as respiratory rate and standard deviation of the ECG-derived respiration, were associated with better clinical outcomes. Correlation analyses showed weak associations between ANS parameters and clinical outcomes when the Multiple Sclerosis phenotype is not taken into account. Blunted autonomic response, in particular HRM reactivity, was related with worse walking capacity, yielding r = 0.36 r = 0.29 (RRMS) and r > 0.5 (SPMS). A positive strong correlation r > 0.7 r > 0.65 between cardiorespiratory parameters derived at hospital and at home was also found.Conclusion: Autonomic function, as measured by HRV, differs according to MS phenotype. Autonomic response to walk tests may be useful for assessing clinical outcomes, mainly in the progressive stage of MS. Participants with larger changes in HRM are able to walk longer distance, while reduced ventilatory function during and after walk test performance is associated with higher fatigue and disability severity scores. Monitoring of disorder severity could also be feasible using ECG-derived cardiac and respiratory parameters recorded with a wearable device at home. info:eu-repo/grantAgreement/EC/H2020/115902/EU/Remote Assessment of Disease and Relapse in Central Nervous System Disorders/RADAR-CNS This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 115902-RADAR-CNS info:eu-repo/grantAgreement/EUR/MICINN/TED2021-131106B-I00 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 3.2 2023 PHYSIOLOGY 24 / 85 = 0.282 2023 Q2 T1 1.006 2023 Physiology (medical) 2023 Q2 Physiology 2023 Q2 6.5 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Laporta, Estela Garcia, Esther Guerrero, Ana Isabel Zabalza, Ana Matteo, Martinis Lucia, Roselli Simblett, Sara Weyer, Janice Hotopf, Matthew Narayan, Vaibhav A. Rashid, Zulqarnain Folarin, Amos A. Dobson, Richard J. B. Buron, Mathias Due Leocani, Letizia Cummins, Nicholas Vairavan, Srinivasan Costa, Gloria Dalla Magyari, Melinda Sørensen, Per Soelberg Nos, Carlos Bailón, Raquel Universidad de Zaragoza (orcid)0000-0003-1272-0550 Comi, Giancarlo the RADAR-CNS Consortium 5008 800 Universidad de Zaragoza Dpto. Ingeniería Electrón.Com. Área Teoría Señal y Comunicac. 14 (2023), 1145818 [13 pp.] Front. physiol. Frontiers in physiology 1664-042X 539754 http://zaguan.unizar.es/record/126425/files/texto_completo.pdf Versión publicada 2582818 http://zaguan.unizar.es/record/126425/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:126425 articulos driver 2024-11-22-12:01:46 ARTICLE