000126436 001__ 126436 000126436 005__ 20241125101147.0 000126436 0247_ $$2doi$$a10.1002/chem.202300116 000126436 0248_ $$2sideral$$a133045 000126436 037__ $$aART-2023-133045 000126436 041__ $$aeng 000126436 100__ $$aGil-Moles, María 000126436 245__ $$aSilver-based terpyridine complexes as antitumor agents 000126436 260__ $$c2023 000126436 5060_ $$aAccess copy available to the general public$$fUnrestricted 000126436 5203_ $$aSilver complexes bearing substituted terpyridine or tetra-2-pyridinylpyrazine ligands have been prepared and structurally characterised. The study of the anticancer properties of silver complexes with this type of ligands is scarce, despite the possibilities of combining the properties of the metal and the ability of the ligands for DNA binding. Here, the antiproliferative activity, stability, CT-DNA binding and mechanism of cell death of these types of derivatives are studied. High cytotoxicity against different tumour cells was observed, and, more important, a great selectivity index has been detected between tumour cells and healthy Lymphocytes T for some of these compounds. The CT-DNA interaction study has shown that these derivatives are be able to interact with CT-DNA via moderate intercalation. Furthermore, cell death studies indicate that these derivatives promote the apoptosis via mitochondrial pathway. 000126436 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FSE/E07-20R$$9info:eu-repo/grantAgreement/ES/MICINN-AEI/RED2018-102471-T$$9info:eu-repo/grantAgreement/ES/MICINN/PID2019-104379RB-C22$$9info:eu-repo/grantAgreement/ES/MINECO/PID2019-104379RB-C21 000126436 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/ 000126436 590__ $$a3.9$$b2023 000126436 592__ $$a1.058$$b2023 000126436 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b80 / 231 = 0.346$$c2023$$dQ2$$eT2 000126436 593__ $$aChemistry (miscellaneous)$$c2023$$dQ1 000126436 593__ $$aOrganic Chemistry$$c2023$$dQ1 000126436 593__ $$aCatalysis$$c2023$$dQ2 000126436 594__ $$a7.9$$b2023 000126436 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000126436 700__ $$aOlmos, M. Elena 000126436 700__ $$aMonge, Miguel 000126436 700__ $$aBeltrán-Visiedo, Manuel$$uUniversidad de Zaragoza 000126436 700__ $$0(orcid)0000-0002-2315-9079$$aMarzo, Isabel$$uUniversidad de Zaragoza 000126436 700__ $$aLópez-de-Luzuriaga, José M. 000126436 700__ $$0(orcid)0000-0003-0553-0695$$aGimeno, M. Concepción 000126436 7102_ $$11002$$2050$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Biología Celular 000126436 773__ $$g29, 37 (2023), e202300116 [12 pp.]$$pChemistry (Weinh.)$$tChemistry - A European Journal$$x0947-6539 000126436 8564_ $$s1768166$$uhttps://zaguan.unizar.es/record/126436/files/texto_completo.pdf$$yVersión publicada 000126436 8564_ $$s2891809$$uhttps://zaguan.unizar.es/record/126436/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000126436 909CO $$ooai:zaguan.unizar.es:126436$$particulos$$pdriver 000126436 951__ $$a2024-11-22-12:05:06 000126436 980__ $$aARTICLE