126436 20241125101147.0 doi 10.1002/chem.202300116 sideral 133045 ART-2023-133045 eng Gil-Moles, María Silver-based terpyridine complexes as antitumor agents 2023 Access copy available to the general public Unrestricted Silver complexes bearing substituted terpyridine or tetra-2-pyridinylpyrazine ligands have been prepared and structurally characterised. The study of the anticancer properties of silver complexes with this type of ligands is scarce, despite the possibilities of combining the properties of the metal and the ability of the ligands for DNA binding. Here, the antiproliferative activity, stability, CT-DNA binding and mechanism of cell death of these types of derivatives are studied. High cytotoxicity against different tumour cells was observed, and, more important, a great selectivity index has been detected between tumour cells and healthy Lymphocytes T for some of these compounds. The CT-DNA interaction study has shown that these derivatives are be able to interact with CT-DNA via moderate intercalation. Furthermore, cell death studies indicate that these derivatives promote the apoptosis via mitochondrial pathway. info:eu-repo/grantAgreement/ES/DGA-FSE/E07-20R info:eu-repo/grantAgreement/ES/MICINN-AEI/RED2018-102471-T info:eu-repo/grantAgreement/ES/MICINN/PID2019-104379RB-C22 info:eu-repo/grantAgreement/ES/MINECO/PID2019-104379RB-C21 info:eu-repo/semantics/openAccess by-nc http://creativecommons.org/licenses/by-nc/3.0/es/ 3.9 2023 CHEMISTRY, MULTIDISCIPLINARY 80 / 231 = 0.346 2023 Q2 T2 1.058 2023 Chemistry (miscellaneous) 2023 Q1 Organic Chemistry 2023 Q1 Catalysis 2023 Q2 7.9 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Olmos, M. Elena Monge, Miguel Beltrán-Visiedo, Manuel Universidad de Zaragoza Marzo, Isabel Universidad de Zaragoza (orcid)0000-0002-2315-9079 López-de-Luzuriaga, José M. Gimeno, M. Concepción (orcid)0000-0003-0553-0695 1002 050 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Biología Celular 29, 37 (2023), e202300116 [12 pp.] Chemistry (Weinh.) Chemistry - A European Journal 0947-6539 1768166 http://zaguan.unizar.es/record/126436/files/texto_completo.pdf Versión publicada 2891809 http://zaguan.unizar.es/record/126436/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:126436 articulos driver 2024-11-22-12:05:06 ARTICLE