000126478 001__ 126478
000126478 005__ 20241125101154.0
000126478 0247_ $$2doi$$a10.1111/jne.13284
000126478 0248_ $$2sideral$$a133921
000126478 037__ $$aART-2023-133921
000126478 041__ $$aeng
000126478 100__ $$aMeunier, Maxime A.
000126478 245__ $$aMale-induced early puberty correlates with the maturation of arcuate nucleus kisspeptin neurons in does
000126478 260__ $$c2023
000126478 5060_ $$aAccess copy available to the general public$$fUnrestricted
000126478 5203_ $$aIn goats, early exposure of spring-born females to sexually active bucks induces an early puberty onset assessed by the first ovulation. This effect is found when females are continuously exposed well before the male breeding season starting in September. The first aim of this study was to evaluate whether a shortened exposure of females to males could also lead to early puberty. We assessed the onset of puberty in Alpine does isolated from bucks (ISOL), exposed to wethers (CAS), exposed to intact bucks from the end of June (INT1), or mid-August (INT2). Intact
bucks became sexually active in mid-September. At the beginning of October, 100% of INT1 and 90% of INT2 exposed does ovulated, in contrast to the ISOL
(0%) and CAS (20%) groups. This demonstrated that contact with males that become sexually active is the main factor prompting precocious puberty in
females. Furthermore, a reduced male exposure during a short window before the breeding season is sufficient to induce this phenomenon. The second aim was to investigate the neuroendocrine changes induced by male exposure. We found a significant increase in kisspeptin immunoreactivity (fiber density and number of cell bodies) in the caudal part of the arcuate nucleus of INT1 and INT2 exposed females. Thus, our results suggest that sensory stimuli from sexually active bucks (e.g., chemosignals) may trigger an early maturation of the ARC kisspeptin neuronal network leading to gonadotropin-releasing hormone secretion and first ovulation.
000126478 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000126478 590__ $$a3.3$$b2023
000126478 592__ $$a1.073$$b2023
000126478 591__ $$aNEUROSCIENCES$$b124 / 310 = 0.4$$c2023$$dQ2$$eT2
000126478 591__ $$aENDOCRINOLOGY & METABOLISM$$b77 / 186 = 0.414$$c2023$$dQ2$$eT2
000126478 593__ $$aEndocrinology, Diabetes and Metabolism$$c2023$$dQ1
000126478 593__ $$aCellular and Molecular Neuroscience$$c2023$$dQ2
000126478 593__ $$aEndocrine and Autonomic Systems$$c2023$$dQ2
000126478 593__ $$aEndocrinology$$c2023$$dQ2
000126478 594__ $$a6.4$$b2023
000126478 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000126478 700__ $$aPorte, Chantal
000126478 700__ $$aPoissenot, Kévin
000126478 700__ $$aVacher, Hélène
000126478 700__ $$aBrachet, Morgane
000126478 700__ $$aChamero, Pablo
000126478 700__ $$aBeltramo, Massimiliano
000126478 700__ $$0(orcid)0000-0003-2827-3054$$aAbecia, José A.$$uUniversidad de Zaragoza
000126478 700__ $$aDelgadillo, José A.
000126478 700__ $$aChemineau, Philippe
000126478 700__ $$aKeller, Matthieu
000126478 7102_ $$12008$$2700$$aUniversidad de Zaragoza$$bDpto. Produc.Animal Cienc.Ali.$$cÁrea Producción Animal
000126478 773__ $$g35, 5 (2023), e13284 [12 pp.]$$pJ. neuroendocrinol.$$tJOURNAL OF NEUROENDOCRINOLOGY$$x0953-8194
000126478 8564_ $$s3251483$$uhttps://zaguan.unizar.es/record/126478/files/texto_completo.pdf$$yVersión publicada
000126478 8564_ $$s1879201$$uhttps://zaguan.unizar.es/record/126478/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000126478 909CO $$ooai:zaguan.unizar.es:126478$$particulos$$pdriver
000126478 951__ $$a2024-11-22-12:08:12
000126478 980__ $$aARTICLE