126478 20241125101154.0 doi 10.1111/jne.13284 sideral 133921 ART-2023-133921 eng Meunier, Maxime A. Male-induced early puberty correlates with the maturation of arcuate nucleus kisspeptin neurons in does 2023 Access copy available to the general public Unrestricted In goats, early exposure of spring-born females to sexually active bucks induces an early puberty onset assessed by the first ovulation. This effect is found when females are continuously exposed well before the male breeding season starting in September. The first aim of this study was to evaluate whether a shortened exposure of females to males could also lead to early puberty. We assessed the onset of puberty in Alpine does isolated from bucks (ISOL), exposed to wethers (CAS), exposed to intact bucks from the end of June (INT1), or mid-August (INT2). Intact bucks became sexually active in mid-September. At the beginning of October, 100% of INT1 and 90% of INT2 exposed does ovulated, in contrast to the ISOL (0%) and CAS (20%) groups. This demonstrated that contact with males that become sexually active is the main factor prompting precocious puberty in females. Furthermore, a reduced male exposure during a short window before the breeding season is sufficient to induce this phenomenon. The second aim was to investigate the neuroendocrine changes induced by male exposure. We found a significant increase in kisspeptin immunoreactivity (fiber density and number of cell bodies) in the caudal part of the arcuate nucleus of INT1 and INT2 exposed females. Thus, our results suggest that sensory stimuli from sexually active bucks (e.g., chemosignals) may trigger an early maturation of the ARC kisspeptin neuronal network leading to gonadotropin-releasing hormone secretion and first ovulation. info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 3.3 2023 NEUROSCIENCES 124 / 310 = 0.4 2023 Q2 T2 ENDOCRINOLOGY & METABOLISM 77 / 186 = 0.414 2023 Q2 T2 1.073 2023 Endocrinology, Diabetes and Metabolism 2023 Q1 Cellular and Molecular Neuroscience 2023 Q2 Endocrine and Autonomic Systems 2023 Q2 Endocrinology 2023 Q2 6.4 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Porte, Chantal Poissenot, Kévin Vacher, Hélène Brachet, Morgane Chamero, Pablo Beltramo, Massimiliano Abecia, José A. Universidad de Zaragoza (orcid)0000-0003-2827-3054 Delgadillo, José A. Chemineau, Philippe Keller, Matthieu 2008 700 Universidad de Zaragoza Dpto. Produc.Animal Cienc.Ali. Área Producción Animal 35, 5 (2023), e13284 [12 pp.] J. neuroendocrinol. JOURNAL OF NEUROENDOCRINOLOGY 0953-8194 3251483 http://zaguan.unizar.es/record/126478/files/texto_completo.pdf Versión publicada 1879201 http://zaguan.unizar.es/record/126478/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:126478 articulos driver 2024-11-22-12:08:12 ARTICLE