000126509 001__ 126509
000126509 005__ 20241125101132.0
000126509 0247_ $$2doi$$a10.3389/fcvm.2023.1118919
000126509 0248_ $$2sideral$$a133995
000126509 037__ $$aART-2023-133995
000126509 041__ $$aeng
000126509 100__ $$0(orcid)0000-0003-3435-4854$$aPérez-Gimeno, Gloria
000126509 245__ $$aDevelopment of a genetic risk score to predict the risk of hypertension in European adolescents from the HELENA study
000126509 260__ $$c2023
000126509 5060_ $$aAccess copy available to the general public$$fUnrestricted
000126509 5203_ $$aIntroductionFrom genome wide association study (GWAS) a large number of single nucleotide polymorphisms (SNPs) have previously been associated with blood pressure (BP) levels. A combination of SNPs, forming a genetic risk score (GRS) could be considered as a useful genetic tool to identify individuals at risk of developing hypertension from early stages in life. Therefore, the aim of our study was to build a GRS being able to predict the genetic predisposition to hypertension (HTN) in European adolescents.MethodsData were extracted from the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) cross-sectional study. A total of 869 adolescents (53% female), aged 12.5–17.5, with complete genetic and BP information were included. The sample was divided into altered (≥130 mmHg for systolic and/or ≥80 mmHg for diastolic) or normal BP. Based on the literature, a total of 1.534 SNPs from 57 candidate genes related with BP were selected from the HELENA GWAS database.ResultsFrom 1,534 SNPs available, An initial screening of SNPs univariately associated with HTN (p < 0.10) was established, to finally obtain a number of 16 SNPs significantly associated with HTN (p < 0.05) in the multivariate model. The unweighted GRS (uGRS) and weighted GRS (wGRS) were estimated. To validate the GRSs, the area under the curve (AUC) was explored using ten-fold internal cross-validation for uGRS (0.802) and wGRS (0.777). Further covariates of interest were added to the analyses, obtaining a higher predictive ability (AUC values of uGRS: 0.879; wGRS: 0.881 for BMI z-score). Furthermore, the differences between AUCs obtained with and without the addition of covariates were statistically significant (p < 0.05).ConclusionsBoth GRSs, the uGRS and wGRS, could be useful to evaluate the predisposition to hypertension in European adolescents.
000126509 536__ $$9info:eu-repo/grantAgreement/EUR/FP6/FOOD-CT-2005-007034$$9info:eu-repo/grantAgreement/EC/H2020/801586/EU/International Doctoral Programme for Talent Attraction to the Campus of International Excellence of the Ebro Valley/IberusTalent$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 801586-IberusTalent$$9info:eu-repo/grantAgreement/ES/ISCIII/PI20-00988
000126509 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000126509 590__ $$a2.8$$b2023
000126509 592__ $$a0.863$$b2023
000126509 591__ $$aCARDIAC & CARDIOVASCULAR SYSTEMS$$b79 / 222 = 0.356$$c2023$$dQ2$$eT2
000126509 593__ $$aCardiology and Cardiovascular Medicine$$c2023$$dQ2
000126509 594__ $$a3.8$$b2023
000126509 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000126509 700__ $$0(orcid)0000-0001-6899-5938$$aSeral-Cortes, Miguel$$uUniversidad de Zaragoza
000126509 700__ $$aSabroso-Lasa, Sergio
000126509 700__ $$0(orcid)0000-0002-3007-302X$$aEsteban, Luis Mariano
000126509 700__ $$aLurbe, Empar
000126509 700__ $$aBéghin, Laurent
000126509 700__ $$aGottrand, Frederic
000126509 700__ $$aMeirhaeghe, Aline
000126509 700__ $$aMuntaner, Manon
000126509 700__ $$aKafatos, Anthony
000126509 700__ $$aMolnár, Dénes
000126509 700__ $$aLeclercq, Catherine
000126509 700__ $$aWidhalm, Kurt
000126509 700__ $$aKersting, Mathilde
000126509 700__ $$aNova, Esther
000126509 700__ $$aSalazar-Tortosa, Diego F.
000126509 700__ $$aGonzalez-Gross, Marcela
000126509 700__ $$aBreidenassel, Christina
000126509 700__ $$aSinningen, Kathrin
000126509 700__ $$aDe Ruyter, Thaïs
000126509 700__ $$aLabayen, Idoia
000126509 700__ $$0(orcid)0000-0002-3850-8235$$aRupérez, Azahara I.
000126509 700__ $$0(orcid)0000-0002-0902-387X$$aBueno-Lozano, Gloria$$uUniversidad de Zaragoza
000126509 700__ $$0(orcid)0000-0003-0454-653X$$aMoreno, Luis A.$$uUniversidad de Zaragoza
000126509 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000126509 7102_ $$11011$$2670$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Pediatría
000126509 773__ $$g10 (2023), [11 pp.]$$pFront. cardiovasc. med.$$tFrontiers in cardiovascular medicine$$x2297-055X
000126509 8564_ $$s657064$$uhttps://zaguan.unizar.es/record/126509/files/texto_completo.pdf$$yVersión publicada
000126509 8564_ $$s2566630$$uhttps://zaguan.unizar.es/record/126509/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000126509 909CO $$ooai:zaguan.unizar.es:126509$$particulos$$pdriver
000126509 951__ $$a2024-11-22-11:59:28
000126509 980__ $$aARTICLE