000126513 001__ 126513
000126513 005__ 20240705134146.0
000126513 0247_ $$2doi$$a10.1111/acps.13546
000126513 0248_ $$2sideral$$a133948
000126513 037__ $$aART-2023-133948
000126513 041__ $$aeng
000126513 100__ $$aValli, Isabel
000126513 245__ $$aObstetric complications and genetic risk for schizophrenia: Differential role of antenatal and perinatal events in first episode psychosis
000126513 260__ $$c2023
000126513 5060_ $$aAccess copy available to the general public$$fUnrestricted
000126513 5203_ $$aBackground: Obstetric complications (OCs) are key contributors to psychosis risk. However, it is unclear whether they increase psychosis vulnerability independently of genetic risk, in interaction with it, or are a manifestation of psychosis proneness. We examined the role of distinct types of OCs in terms of psychosis risk and tested whether they interact differently with genetic vulnerability, whilst accounting for other known environmental risk factors.
Study Design: 405 participants (219 first episode psychosis patients and 186 healthy volunteers) underwent a comprehensive assessment of OCs, measured using the Lewis-Murray scale and divided into complications of pregnancy, abnormalities of foetal growth and development, and complications of delivery. Participants were compared in terms of history of OCs, polygenic risk score for schizophrenia (PRS-SZ) and interactions between these.
Results: Both complications of pregnancy and abnormalities of foetal growth were significantly associated with case–control status (p = 0.02 and 0.03, respectively), whereas complications of delivery were not. PRS-SZ showed a significant association with psychosis (p = 0.04), but there were no significant interactions between genetic risk for schizophrenia and OCs, either when these were considered globally or separated based on their timeframe.
Conclusions: We observed no significant interaction between genetic and obstetric vulnerability, yet distinct types of OCs may have a different impact on psychosis risk, based on their nature and timeframe. Examining their differential role might clarify their relative contributions to this risk.
000126513 536__ $$9info:eu-repo/grantAgreement/EC/H2020/754550/EU/Biomedicine international training research programme for excellent clinician-scientists/BITRECS$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 754550-BITRECS$$9info:eu-repo/grantAgreement/ES/ISCIII/PI20-00661$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/CIBERSAM$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII-FEDER/PI08-0208$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII-FEDER/PI11-00325$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII-FEDER/PI14-00612
000126513 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000126513 592__ $$a2.615$$b2023
000126513 593__ $$aPsychiatry and Mental Health$$c2023$$dQ1
000126513 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000126513 700__ $$aGonzalez Segura, Alex
000126513 700__ $$aVerdolini, Norma
000126513 700__ $$aGarcia-Rizo, Clemente
000126513 700__ $$aBerge, Daniel
000126513 700__ $$aBaeza, Inmaculada
000126513 700__ $$aCuesta, Manuel J.
000126513 700__ $$aGonzalez-Pinto, Ana
000126513 700__ $$0(orcid)0000-0002-9098-655X$$aLobo, Antonio$$uUniversidad de Zaragoza
000126513 700__ $$aMartinez-Aran, Anabel
000126513 700__ $$aMezquida, Gisela
000126513 700__ $$aPina-Camacho, Laura
000126513 700__ $$aRoldan Bejarano, Alexandra
000126513 700__ $$aMas, Sergi
000126513 700__ $$aMcGuire, Philip
000126513 700__ $$aBernardo, Miquel
000126513 700__ $$aVieta, Eduard
000126513 700__ $$a
000126513 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Psiquiatría
000126513 773__ $$g148, 1 (2023), 81-90$$pActa psychiatr. Scand.$$tActa Psychiatrica Scandinavica$$x0001-690X
000126513 8564_ $$s1266687$$uhttps://zaguan.unizar.es/record/126513/files/texto_completo.pdf$$yVersión publicada
000126513 8564_ $$s2239827$$uhttps://zaguan.unizar.es/record/126513/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000126513 909CO $$ooai:zaguan.unizar.es:126513$$particulos$$pdriver
000126513 951__ $$a2024-07-05-12:47:25
000126513 980__ $$aARTICLE