000126528 001__ 126528
000126528 005__ 20241125101140.0
000126528 0247_ $$2doi$$a10.1016/j.euros.2023.03.013
000126528 0248_ $$2sideral$$a133996
000126528 037__ $$aART-2023-133996
000126528 041__ $$aeng
000126528 100__ $$aMorote, Juan
000126528 245__ $$aComparison of Rotterdam and Barcelona magnetic resonance imaging risk calculators for predicting clinically significant prostate cancer
000126528 260__ $$c2023
000126528 5060_ $$aAccess copy available to the general public$$fUnrestricted
000126528 5203_ $$aBackground: Magnetic resonance imaging (MRI)-based risk calculators (MRI-RCs) individualise the likelihood of clinically significant prostate cancer (csPCa) and improve candidate selection for prostate biopsy beyond the Prostate Imaging Reporting and Data System (PI-RADS). Objective: To compare the Barcelona (BCN) and Rotterdam (ROT) MRI-RCs in an entire population and according to the PI-RADS categories. Design, setting, and participants: A prospective comparison of BCN- and ROT-RC in 946 men with suspected prostate cancer in whom systematic biopsy was performed, as well as target biopsies of PI-RADS ≥3 lesions. Outcome measurements and statistical analysis: Saved biopsies and undetected csPCa (grade group ≥2) were determined. Results and limitations: The csPCa detection was 40.8%. The median risks of csPCa from BCN- and ROT-RC were, respectively, 67.1% and 25% in men with csPCa, whereas 10.5% and 3% in those without csPCa (p < 0.001). The areas under the curve were 0.856 and 0.844, respectively (p = 0.116). BCN-RC showed a higher net benefit and clinical utility over ROT-RC. Using appropriate thresholds, respectively, 75% and 80% of biopsies were needed to identify 50% of csPCa detected in men with PI-RADS <3, whereas 35% and 21% of biopsies were saved, missing 10% of csPCa detected in men with PI-RADS 3. BCN-RC saved 15% of biopsies, missing 2% of csPCa in men with PI-RADS 4, whereas ROT-RC saved 10%, missing 6%. No RC saved biopsies without missing csPCa in men with PI-RADS 5. Conclusions: ROT-RC provided a lower and narrower range of csPCa probabilities than BCN-RC. BCN-RC showed a net benefit over ROT-RC in the entire population. However, BCN-RC was useful in men with PI-RADS 3 and 4, whereas ROT-RC was useful only in those with PI-RADS 3. No RC seemed to be helpful in men with negative MRI and PI-RADS 5.
000126528 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/PI20/01666
000126528 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000126528 590__ $$a3.2$$b2023
000126528 592__ $$a0.924$$b2023
000126528 591__ $$aUROLOGY & NEPHROLOGY$$b24 / 126 = 0.19$$c2023$$dQ1$$eT1
000126528 593__ $$aUrology$$c2023$$dQ1
000126528 594__ $$a3.4$$b2023
000126528 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000126528 700__ $$0(orcid)0000-0003-0178-4567$$aBorque-Fernando, Ángel$$uUniversidad de Zaragoza
000126528 700__ $$aTriquell, Marina
000126528 700__ $$aCampistol, Miriam
000126528 700__ $$aServian, Pol
000126528 700__ $$aAbascal, José M.
000126528 700__ $$aPlanas, Jacques
000126528 700__ $$aMéndez, Olga
000126528 700__ $$0(orcid)0000-0002-3007-302X$$aEsteban, Luis M.
000126528 700__ $$aTrilla, Enrique
000126528 7102_ $$11013$$2817$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Urología
000126528 773__ $$g53 (2023), 46-54$$pEur. urol. open sci.$$tEuropean urology open science$$x2666-1691
000126528 8564_ $$s1819363$$uhttps://zaguan.unizar.es/record/126528/files/texto_completo.pdf$$yVersión publicada
000126528 8564_ $$s2235080$$uhttps://zaguan.unizar.es/record/126528/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000126528 909CO $$ooai:zaguan.unizar.es:126528$$particulos$$pdriver
000126528 951__ $$a2024-11-22-12:02:14
000126528 980__ $$aARTICLE