126528 20241125101140.0 doi 10.1016/j.euros.2023.03.013 sideral 133996 ART-2023-133996 eng Morote, Juan Comparison of Rotterdam and Barcelona magnetic resonance imaging risk calculators for predicting clinically significant prostate cancer 2023 Access copy available to the general public Unrestricted Background: Magnetic resonance imaging (MRI)-based risk calculators (MRI-RCs) individualise the likelihood of clinically significant prostate cancer (csPCa) and improve candidate selection for prostate biopsy beyond the Prostate Imaging Reporting and Data System (PI-RADS). Objective: To compare the Barcelona (BCN) and Rotterdam (ROT) MRI-RCs in an entire population and according to the PI-RADS categories. Design, setting, and participants: A prospective comparison of BCN- and ROT-RC in 946 men with suspected prostate cancer in whom systematic biopsy was performed, as well as target biopsies of PI-RADS ≥3 lesions. Outcome measurements and statistical analysis: Saved biopsies and undetected csPCa (grade group ≥2) were determined. Results and limitations: The csPCa detection was 40.8%. The median risks of csPCa from BCN- and ROT-RC were, respectively, 67.1% and 25% in men with csPCa, whereas 10.5% and 3% in those without csPCa (p < 0.001). The areas under the curve were 0.856 and 0.844, respectively (p = 0.116). BCN-RC showed a higher net benefit and clinical utility over ROT-RC. Using appropriate thresholds, respectively, 75% and 80% of biopsies were needed to identify 50% of csPCa detected in men with PI-RADS <3, whereas 35% and 21% of biopsies were saved, missing 10% of csPCa detected in men with PI-RADS 3. BCN-RC saved 15% of biopsies, missing 2% of csPCa in men with PI-RADS 4, whereas ROT-RC saved 10%, missing 6%. No RC saved biopsies without missing csPCa in men with PI-RADS 5. Conclusions: ROT-RC provided a lower and narrower range of csPCa probabilities than BCN-RC. BCN-RC showed a net benefit over ROT-RC in the entire population. However, BCN-RC was useful in men with PI-RADS 3 and 4, whereas ROT-RC was useful only in those with PI-RADS 3. No RC seemed to be helpful in men with negative MRI and PI-RADS 5. info:eu-repo/grantAgreement/ES/ISCIII/PI20/01666 info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 3.2 2023 UROLOGY & NEPHROLOGY 24 / 126 = 0.19 2023 Q1 T1 0.924 2023 Urology 2023 Q1 3.4 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Borque-Fernando, Ángel Universidad de Zaragoza (orcid)0000-0003-0178-4567 Triquell, Marina Campistol, Miriam Servian, Pol Abascal, José M. Planas, Jacques Méndez, Olga Esteban, Luis M. (orcid)0000-0002-3007-302X Trilla, Enrique 1013 817 Universidad de Zaragoza Dpto. Cirugía Área Urología 53 (2023), 46-54 Eur. urol. open sci. European urology open science 2666-1691 1819363 http://zaguan.unizar.es/record/126528/files/texto_completo.pdf Versión publicada 2235080 http://zaguan.unizar.es/record/126528/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:126528 articulos driver 2024-11-22-12:02:14 ARTICLE