126541 20250210083428.0 doi 10.3390/ph16050772 sideral 133991 ART-2023-133991 eng Avedillo-Salas, Ana Universidad de Zaragoza (orcid)0000-0003-2153-0417 Prescribed drugs and self-directed violence: a descriptive study in the spanish pharmacovigilance database 2023 Access copy available to the general public Unrestricted Self-inflicted violence is a major and growing public health problem and its prediction and prevention is challenging for healthcare systems worldwide. Our aim was to identify prescribed drugs associated with self-directed violent behaviors in Spain. A descriptive, longitudinal and retrospective study of spontaneous reports of adverse drug reactions corresponding to self-directed violence was recorded in the Spanish Pharmacovigilance Database (FEDRA®) from 1984 to 31 March 2021. A total of 710 cases were reported in the study period. The mean age was 45.52 years (range 1–94). There were no gender differences except in children, where most reports were of male children. The main therapeutic groups that were involved included drugs for the nervous system (64.5%) and anti-infectives for systemic use (13.2%). The most commonly reported drugs were varenicline, fluoxetine, lorazepam, escitalopram, venlafaxine, veralipride, pregabalin, roflumilast and bupropion. There were reports of montelukast, hydroxychloroquine, isotretinoin, methylphenidate, infliximab, natalizumab, ribavirin and efavirenz, which were less known to be involved in self-directed violence. This study shows that self-directed violence is a rare adverse drug reaction, and can be related to the use of some medicines. It is important for healthcare professionals to consider this risk in their clinical praxis, implementing person-centred approaches. Further studies are needed, considering comorbidities and potential interactions. info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.3 2023 PHARMACOLOGY & PHARMACY 69 / 354 = 0.195 2023 Q1 T1 CHEMISTRY, MEDICINAL 20 / 72 = 0.278 2023 Q2 T1 0.845 2023 Pharmaceutical Science 2023 Q1 Drug Discovery 2023 Q2 Molecular Medicine 2023 Q2 6.1 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Pueyo-Val, Javier Universidad de Zaragoza Fanlo-Villacampa, Ana Universidad de Zaragoza (orcid)0000-0001-8064-8138 Navarro-Pemán, Cristina Universidad de Zaragoza (orcid)0000-0002-7239-1966 Lanuza-Giménez, Francisco Javier Universidad de Zaragoza (orcid)0000-0002-6485-1926 Ioakeim-Skoufa, Ignatios Vicente-Romero, Jorge Universidad de Zaragoza (orcid)0000-0003-4629-6743 1012 315 Universidad de Zaragoza Dpto. Farmac.Fisiol.y Med.L.F. Área Farmacología 16, 5 (2023), 772 [14 pp.] Pharmaceuticals Pharmaceuticals 1424-8247 1713632 http://zaguan.unizar.es/record/126541/files/texto_completo.pdf Versión publicada 2610965 http://zaguan.unizar.es/record/126541/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:126541 articulos driver 2025-02-10-08:31:23 ARTICLE