000126547 001__ 126547
000126547 005__ 20240319081031.0
000126547 0247_ $$2doi$$a10.18632/aging.203898
000126547 0248_ $$2sideral$$a134041
000126547 037__ $$aART-2022-134041
000126547 041__ $$aeng
000126547 100__ $$aBlanco, Jose Ramón
000126547 245__ $$aElevated levels of serum CDCP1 in individuals recovering from severe COVID-19 disease
000126547 260__ $$c2022
000126547 5060_ $$aAccess copy available to the general public$$fUnrestricted
000126547 5203_ $$aBackground: COVID-19 survivors report residual lung abnormalities after discharge from the hospital. The aim of this study was to identify biomarkers in serum and induced sputum samples from patients after hospitalization for COVID-19.
Methods: Patients admitted to hospitals in Spain with laboratory-confirmed COVID-19 were recruited for this study. SARS-CoV-2-infected patients were divided into groups with mild/moderate and severe disease according to the severity of their symptoms during hospitalization. Levels of 92 biomarkers were measured in serum and induced sputum samples.
Results: A total of 108 patients (46.2% severe cases) were included in this study. The median number of days after the onset of symptoms was 104. A significant difference was observed in diffusing capacity for carbon monoxide (DLCO), an indicator of lung function, whereby DLCO <80% was significantly lower in severe cases (p <0.001). Differences in inflammatory biomarkers were observed between patients with mild/moderate and severe disease. For some biomarkers, correlations in serum and induced sputum levels were detected. Independent predictors of severe disease were DLCO <80% and the serum CDCP1 value.
Conclusions: Higher levels of CDCP1 remain after hospital discharge and are associated with the severity of COVID-19. The possible prognostic implications warrant further investigation.
000126547 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/COV20-00401
000126547 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000126547 592__ $$a1.2$$b2022
000126547 590__ $$a5.2$$b2022
000126547 593__ $$aCell Biology$$c2022$$dQ2
000126547 591__ $$aGERIATRICS & GERONTOLOGY$$b17 / 54 = 0.315$$c2022$$dQ2$$eT1
000126547 593__ $$aAging$$c2022$$dQ2
000126547 591__ $$aCELL BIOLOGY$$b73 / 191 = 0.382$$c2022$$dQ2$$eT2
000126547 594__ $$a9.3$$b2022
000126547 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000126547 700__ $$aCobos-Ceballos, María Jesús
000126547 700__ $$aNavarro, Francisco
000126547 700__ $$0(orcid)0000-0003-1436-4334$$aSanjoaquin, Isabel$$uUniversidad de Zaragoza
000126547 700__ $$aArmiñanzas, Carlos
000126547 700__ $$aBernal, Enrique
000126547 700__ $$aBuzon-Martin, Luis
000126547 700__ $$aViribay, Miguel
000126547 700__ $$aPérez-Martínez, Laura
000126547 700__ $$aEspejo-Pérez, Simona
000126547 700__ $$aValencia, Borja
000126547 700__ $$aGuzman-Aguilar, Jesus$$uUniversidad de Zaragoza
000126547 700__ $$aRuiz-Cubillan, Juan-Jose
000126547 700__ $$aAlcalde, Consuelo
000126547 700__ $$aGutierrez-Herrero, Fernando Gustavo
000126547 700__ $$aOlalla, Julian
000126547 700__ $$aAndres-Esteban, Eva-Maria
000126547 700__ $$aJurado-Gamez, Bernabe
000126547 700__ $$aUgedo, Javier
000126547 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000126547 773__ $$g14, 4 (2022), 1597-1610$$pAGING-US$$tAGING-US$$x1945-4589
000126547 8564_ $$s820108$$uhttps://zaguan.unizar.es/record/126547/files/texto_completo.pdf$$yVersión publicada
000126547 8564_ $$s2508254$$uhttps://zaguan.unizar.es/record/126547/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000126547 909CO $$ooai:zaguan.unizar.es:126547$$particulos$$pdriver
000126547 951__ $$a2024-03-18-17:08:17
000126547 980__ $$aARTICLE