126584 20241125101133.0 doi 10.3390/ijms24108573 sideral 134093 ART-2023-134093 eng Vázquez-Morón, Sonia Enhancing SARS-CoV-2 Surveillance through Regular Genomic Sequencing in Spain: The RELECOV Network 2023 Access copy available to the general public Unrestricted Millions of SARS-CoV-2 whole genome sequences have been generated to date. However, good quality data and adequate surveillance systems are required to contribute to meaningful surveillance in public health. In this context, the network of Spanish laboratories for coronavirus (RELECOV) was created with the main goal of promoting actions to speed up the detection, analyses, and evaluation of SARS-CoV-2 at a national level, partially structured and financed by an ECDC-HERA-Incubator action (ECDC/GRANT/2021/024). A SARS-CoV-2 sequencing quality control assessment (QCA) was developed to evaluate the network’s technical capacity. QCA full panel results showed a lower hit rate for lineage assignment compared to that obtained for variants. Genomic data comprising 48,578 viral genomes were studied and evaluated to monitor SARS-CoV-2. The developed network actions showed a 36% increase in sharing viral sequences. In addition, analysis of lineage/sublineage-defining mutations to track the virus showed characteristic mutation profiles for the Delta and Omicron variants. Further, phylogenetic analyses strongly correlated with different variant clusters, obtaining a robust reference tree. The RELECOV network has made it possible to improve and enhance the genomic surveillance of SARS-CoV-2 in Spain. It has provided and evaluated genomic tools for viral genome monitoring and characterization that make it possible to increase knowledge efficiently and quickly, promoting the genomic surveillance of SARS-CoV-2 in Spain. info:eu-repo/grantAgreement/ES/ISCIII/COV20-00679 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.9 2023 BIOCHEMISTRY & MOLECULAR BIOLOGY 66 / 313 = 0.211 2023 Q1 T1 CHEMISTRY, MULTIDISCIPLINARY 68 / 231 = 0.294 2023 Q2 T1 1.179 2023 Medicine (miscellaneous) 2023 Q1 Physical and Theoretical Chemistry 2023 Q1 Computer Science Applications 2023 Q1 Inorganic Chemistry 2023 Q1 Spectroscopy 2023 Q1 Organic Chemistry 2023 Q1 Molecular Biology 2023 Q2 Catalysis 2023 Q2 8.1 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Iglesias-Caballero, María Lepe, José Garcia, Federico Melón, Santiago Marimon, José García de Viedma, Darío Folgueira, Maria Galán, Juan López-Causapé, Carla Benito-Ruesca, Rafael Universidad de Zaragoza (orcid)0000-0001-5134-1006 Alcoba-Florez, Julia Gonzalez Candelas, Fernando Toro, María Fajardo, Miguel Ezpeleta, Carmen Lázaro, Fernando Pérez Castro, Sonia Cuesta, Isabel Zaballos, Angel Pozo, Francisco Casas, Inmaculada on behalf of RELECOV Network Members 1011 630 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Microbiología 24, 10 (2023), 8573 [17 pp.] Int. j. mol. sci. International Journal of Molecular Sciences 1661-6596 1987887 http://zaguan.unizar.es/record/126584/files/texto_completo.pdf Versión publicada 2791311 http://zaguan.unizar.es/record/126584/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:126584 articulos driver 2024-11-22-11:59:30 ARTICLE