000126585 001__ 126585
000126585 005__ 20241125101133.0
000126585 0247_ $$2doi$$a10.3390/biomedicines11071940
000126585 0248_ $$2sideral$$a134076
000126585 037__ $$aART-2023-134076
000126585 041__ $$aeng
000126585 100__ $$0(orcid)0000-0003-3957-3749$$aEsteban-Zubero, Eduardo$$uUniversidad de Zaragoza
000126585 245__ $$aMelatonin preserves fluidity in cell and mitochondrial membranes against hepatic ischemia–reperfusion
000126585 260__ $$c2023
000126585 5060_ $$aAccess copy available to the general public$$fUnrestricted
000126585 5203_ $$aWe evaluated the in vivo effects of melatonin treatment on oxidative damage in the liver in an experimental model of ischemia–reperfusion. A total of 37 male Sprague-Dawley rats were randomly divided into four groups: control, ischemia, ischemia + reperfusion, and ischemia + reperfusion + melatonin. Hepatic ischemia was maintained for 20 min, and the clamp was removed to initiate vascular reperfusion for 30 min. Melatonin (50 mg/kg body weight) was intraperitoneally administered. Fluidity was measured by polarization changes in 1-(4-trimethylammoniumphenyl)-6-phenyl-1,3,5-hexatriene-p-toluene sulfonate). After 20 min of ischemia, no significant changes were observed in cell and mitochondrial membrane fluidity levels, lipid peroxidation, and protein carbonylation. However, after 30 min of reperfusion, membrane fluidity decreased compared to controls. Increases in lipid and protein oxidation were also seen in hepatic homogenates of animals exposed to reperfusion. Melatonin injected 30 min before ischemia and reperfusion fully prevented membrane rigidity and both lipid and protein oxidation. Livers from ischemia–reperfusion showed histopathological alterations and positive labeling with antibodies to oxidized lipids and proteins. Melatonin reduced the severity of these morphological changes and protected against in vivo ischemia–reperfusion-induced toxicity in the liver. Therefore, melatonin might be a candidate for co-treatment for patients with hepatic vascular occlusion followed by reperfusion.
000126585 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B56-23D
000126585 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000126585 590__ $$a3.9$$b2023
000126585 592__ $$a0.962$$b2023
000126585 591__ $$aPHARMACOLOGY & PHARMACY$$b85 / 354 = 0.24$$c2023$$dQ1$$eT1
000126585 593__ $$aMedicine (miscellaneous)$$c2023$$dQ1
000126585 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b106 / 313 = 0.339$$c2023$$dQ2$$eT2
000126585 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2023$$dQ1
000126585 591__ $$aMEDICINE, RESEARCH & EXPERIMENTAL$$b65 / 189 = 0.344$$c2023$$dQ2$$eT2
000126585 594__ $$a5.2$$b2023
000126585 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000126585 700__ $$0(orcid)0000-0002-2455-680X$$aLópez-Pingarrón, Laura$$uUniversidad de Zaragoza
000126585 700__ $$0(orcid)0000-0001-7964-1166$$aRamirez, José Manuel$$uUniversidad de Zaragoza
000126585 700__ $$0(orcid)0000-0002-2323-2053$$aReyes-Gonzales, Marcos César$$uUniversidad de Zaragoza
000126585 700__ $$0(orcid)0000-0001-8323-0984$$aAzúa-Romeo, Francisco Javier$$uUniversidad de Zaragoza
000126585 700__ $$0(orcid)0000-0002-6001-2738$$aSoria-Aznar, Marisol$$uUniversidad de Zaragoza
000126585 700__ $$aAgil, Ahmad
000126585 700__ $$0(orcid)0000-0001-9507-6478$$aGarcía, José Joaquín$$uUniversidad de Zaragoza
000126585 7102_ $$11012$$2410$$aUniversidad de Zaragoza$$bDpto. Farmac.Fisiol.y Med.L.F.$$cÁrea Fisiología
000126585 7102_ $$11003$$2443$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Histología
000126585 7102_ $$11013$$2090$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Cirugía
000126585 773__ $$g11, 7 (2023), 1940 [13 pp.]$$tBiomedicines$$x2227-9059
000126585 8564_ $$s1572597$$uhttps://zaguan.unizar.es/record/126585/files/texto_completo.pdf$$yVersión publicada
000126585 8564_ $$s2674744$$uhttps://zaguan.unizar.es/record/126585/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000126585 909CO $$ooai:zaguan.unizar.es:126585$$particulos$$pdriver
000126585 951__ $$a2024-11-22-11:59:42
000126585 980__ $$aARTICLE