126596 20241125101140.0 doi 10.1039/D3LC00136A sideral 134087 ART-2023-134087 eng Lafuente, Marta (orcid)0000-0003-2660-3726 On-chip monitoring of toxic gases: capture and label-free SERS detection with plasmonic mesoporous sorbents 2023 Access copy available to the general public Unrestricted AThe detection of the spread of toxic gas molecules in the air at low concentration in the field requires a robust miniaturized system combined with an analytical technique that is portable and able to detect and identify the molecules, as is the case with surface enhanced Raman scattering (SERS). This work aims to address capability gaps faced by first responders in real-time detection, identification and monitoring of neurotoxic gases by developing robust, reliable and reusable SERS microfluidic chips. Thus, the key performance attributes of a portable SERS detection system that must be addressed in detail are its limit of detection, response time and reusability. To this purpose, we integrate a 3D plasmonic architecture based on closely packed mesoporous silica (MCM48) nanospheres decorated with Au nanoparticle arrays, denoted as MCM48@Au, into a Si microfluidic chip designed and used for preconcentration and label-free detection of gases at a trace concentration level. The SERS performance of the plasmonic platform is thoroughly analyzed using DMMP as a model neurotoxic simulant over a 1 cm2 SERS active area and over a range of concentrations from 100 ppbV to 2.5 ppmV. The preconcentration-based SERS signal amplification by the mesoporous silica moieties is evaluated against dense silica counterparts, denoted as Stöber@Au. To assess the potential for applications in the field, the microfluidic SERS chip has been interrogated with a portable Raman spectrometer, evaluated with temporal and spatial resolution and subjected to several gas detection/regeneration cycles. The reusable SERS chip shows exceptional performance for the label-free monitoring of 2.5 ppmV gaseous DMMP. info:eu-repo/grantAgreement/ES/DGA/E13-20R info:eu-repo/grantAgreement/ES/DGA-FEDER/T57-17R info:eu-repo/grantAgreement/EC/H2020/823717/EU/Enabling Science and Technology through European Electron Microscopy/ESTEEM3 This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 823717-ESTEEM3 info:eu-repo/grantAgreement/EC/H2020/823895/EU/SMART SENSING FOR RAPID RESPONSE TO CHEMICAL THREATS ON SOFT TARGETS/SENSOFT This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 823895-SENSOFT info:eu-repo/grantAgreement/EC/H2020/883390/EU/Advanced Surface Enhanced Raman Spectroscopy (SERS) based technologies for gas and liquids sensING in the area of chemical protection/SERSing This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 883390-SERSing info:eu-repo/grantAgreement/ES/MICINN-AEI/PID2019-104739GB-I00/AEI-10.13039-501100011033 info:eu-repo/grantAgreement/ES/MICINN/PID2019-108660RB-I00 info:eu-repo/semantics/openAccess by-nc http://creativecommons.org/licenses/by-nc/3.0/es/ 6.1 2023 BIOCHEMICAL RESEARCH METHODS 5 / 85 = 0.059 2023 Q1 T1 CHEMISTRY, ANALYTICAL 8 / 106 = 0.075 2023 Q1 T1 INSTRUMENTS & INSTRUMENTATION 7 / 76 = 0.092 2023 Q1 T1 CHEMISTRY, MULTIDISCIPLINARY 51 / 231 = 0.221 2023 Q1 T1 NANOSCIENCE & NANOTECHNOLOGY 39 / 141 = 0.277 2023 Q2 T1 1.246 2023 Biochemistry 2023 Q1 Bioengineering 2023 Q1 Biomedical Engineering 2023 Q1 Chemistry (miscellaneous) 2023 Q1 Nanoscience and Nanotechnology 2023 Q2 11.1 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Almazán, Fernando (orcid)0000-0001-5063-2987 Bernad, Eduardo Florea, Ileana Arenal, Raul (orcid)0000-0002-2071-9093 Urbiztondo, Miguel A. (orcid)0000-0002-4931-1358 Mallada, Reyes Universidad de Zaragoza (orcid)0000-0002-4758-9380 Pina, Maria P. Universidad de Zaragoza (orcid)0000-0001-9897-6527 5005 555 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Ingeniería Química 23, 14 (2023), 3160–3171 Lab chip Lab on a chip 1473-0197 3629313 http://zaguan.unizar.es/record/126596/files/texto_completo.pdf Versión publicada 1909804 http://zaguan.unizar.es/record/126596/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:126596 articulos driver 2024-11-22-12:02:17 ARTICLE