Resumen: We report on a systematic characterization of microbulk Micromegas readouts in high-pressure Ar+1%iC4H10 and Ne+2%iC4H10 mixtures. Experimental data on gain, electron transmission and energy resolution are presented for a wide range of drift and amplification voltages and pressures from 1 bar to 10 bar for the argon mixture and from 5 bar to 10 bar in the neon mixture, in steps of 1 bar. Maximum gains higher than 1.7 × 103 (1.7 × 104) in the argon (neon) mixture are measured for all pressures, without the significant decrease with pressure typically observed in other amplification structures. A competitive energy resolution at 22.1 keV, but with a slight degradation with pressure, is observed: from 10.8% at 1 bar to 15.6% FWHM at 10 bar in Ar+1%iC4H10 and from 8.3% at 5 bar to 15.0% FWHM at 10 bar in Ne+2%iC4H10. The experimental setup, procedure and the results will be presented and discussed in detail. The work is motivated by the TREX-DM experiment, that is operating in the Laboratorio Subterráneo de Canfranc with the mentioned mixtures, although the results may be of interest for other applications of time projection chambers at high pressures. Idioma: Inglés DOI: 10.1088/1748-0221/17/07/P07032 Año: 2022 Publicado en: Journal of Instrumentation 17, 7 (2022), P07032 [11 pp.] ISSN: 1748-0221 Factor impacto JCR: 1.3 (2022) Categ. JCR: INSTRUMENTS & INSTRUMENTATION rank: 52 / 63 = 0.825 (2022) - Q4 - T3 Factor impacto CITESCORE: 2.2 - Mathematics (Q2) - Physics and Astronomy (Q3)