000126792 001__ 126792
000126792 005__ 20250520101729.0
000126792 0247_ $$2doi$$a10.1016/j.arteri.2023.04.003
000126792 0248_ $$2sideral$$a134119
000126792 037__ $$aART-2023-134119
000126792 041__ $$aeng
000126792 100__ $$0(orcid)0000-0001-6650-8294$$aMateo-Gallego, Rocío$$uUniversidad de Zaragoza
000126792 245__ $$aAbsence of the influence of the APOE gene on the incidence of type 2 diabetes mellitus in a cohort of workers: Effect of diet and shift work
000126792 260__ $$c2023
000126792 5060_ $$aAccess copy available to the general public$$fUnrestricted
000126792 5203_ $$aAPOE gene encoded a multifunctional protein in lipid metabolism, also associated with inflammatory markers. Type 2 diabetes (T2D) is a complex metabolic disease related to increased blood glucose, triglycerides and VLDL and associated with different dyslipidaemias. The aim of this study was to analyze whether the APOE genotype could determining the risk of developing T2D in a large cohort of workers.
Material and methods
Data from the Aragon Workers Health Study (AWHS) (n = 4895) were used to investigate the relationship between glycemic levels and APOE genotype. All patients in the AWHS cohort had their blood drawn after an overnight fast and laboratory tests were performed on the same day as the blood drawn. Dietary and physical assessment was assessed by face-to-face interview. APOE genotype was determined by the Sanger sequencing method.
Results
The relationship between APOE genotype and glycemic profile showed that glucose, Hb1Ac, insulin and HOMA levels did not seem to be associated with the APOE genotype (p = 0.563, p = 0.605, p = 0.333 and p = 0.276, respectively). In addition, the T2D prevalence did not show an association with the APOE genotype (p = 0.354). Along the same lines, blood glucose levels and T2D prevalence did not show association with the APOE allele. Shift work had some effect on the glycaemic profile, showing that night shift workers have significantly lower levels of glucose, insulin and HOMA (p < 0.001). However, the APOE genotype did not show difference in the concentration of glycaemic parameters adjusting by sex, age and BMI, work shift and dietary parameters.
Conclusion
Glycemic profile and T2D prevalence did not show any significant association with the APOE genotype. Besides, individuals, who worked in non-rotating night shift showed significantly lower glycemic levels, while workers in the morning-afternoon-night shift showed significantly higher values.
000126792 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI19-00694$$9info:eu-repo/grantAgreement/ES/MINECO/PI18-01777
000126792 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000126792 592__ $$a0.424$$b2023
000126792 593__ $$aPharmacology (medical)$$c2023$$dQ3
000126792 593__ $$aCardiology and Cardiovascular Medicine$$c2023$$dQ3
000126792 594__ $$a3.2$$b2023
000126792 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000126792 700__ $$0(orcid)0000-0002-1894-1621$$aPérez-Calahorra, Sofía$$uUniversidad de Zaragoza
000126792 700__ $$aBea, Ana M.
000126792 700__ $$0(orcid)0000-0003-1028-8581$$aGracia-Rubio, Irene$$uUniversidad de Zaragoza
000126792 700__ $$0(orcid)0000-0002-1940-2208$$aRodrigo-Carbo, Carmen
000126792 700__ $$0(orcid)0000-0003-0604-5042$$aMoreno-Franco, Belen$$uUniversidad de Zaragoza
000126792 700__ $$0(orcid)0000-0001-7043-0952$$aCiveira, Fernando$$uUniversidad de Zaragoza
000126792 700__ $$0(orcid)0000-0003-3963-0846$$aLaclaustra, Martín$$uUniversidad de Zaragoza
000126792 700__ $$0(orcid)0000-0002-9647-0108$$aLamiquiz-Moneo, Itziar$$uUniversidad de Zaragoza
000126792 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000126792 7102_ $$11003$$2027$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Anatom.Embriol.Humana
000126792 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000126792 7102_ $$11011$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Medic.Prevent.Salud Públ.
000126792 773__ $$g35, 5 (2023), 226-235$$pClín. investig. arterioscler.$$tClinica e Investigacion en Arteriosclerosis$$x0214-9168
000126792 8564_ $$s1408466$$uhttps://zaguan.unizar.es/record/126792/files/texto_completo.pdf$$yPostprint
000126792 8564_ $$s1434508$$uhttps://zaguan.unizar.es/record/126792/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000126792 909CO $$ooai:zaguan.unizar.es:126792$$particulos$$pdriver
000126792 951__ $$a2025-05-20-10:14:04
000126792 980__ $$aARTICLE