126792 20250520101729.0 doi 10.1016/j.arteri.2023.04.003 sideral 134119 ART-2023-134119 eng Mateo-Gallego, Rocío Universidad de Zaragoza (orcid)0000-0001-6650-8294 Absence of the influence of the APOE gene on the incidence of type 2 diabetes mellitus in a cohort of workers: Effect of diet and shift work 2023 Access copy available to the general public Unrestricted APOE gene encoded a multifunctional protein in lipid metabolism, also associated with inflammatory markers. Type 2 diabetes (T2D) is a complex metabolic disease related to increased blood glucose, triglycerides and VLDL and associated with different dyslipidaemias. The aim of this study was to analyze whether the APOE genotype could determining the risk of developing T2D in a large cohort of workers. Material and methods Data from the Aragon Workers Health Study (AWHS) (n = 4895) were used to investigate the relationship between glycemic levels and APOE genotype. All patients in the AWHS cohort had their blood drawn after an overnight fast and laboratory tests were performed on the same day as the blood drawn. Dietary and physical assessment was assessed by face-to-face interview. APOE genotype was determined by the Sanger sequencing method. Results The relationship between APOE genotype and glycemic profile showed that glucose, Hb1Ac, insulin and HOMA levels did not seem to be associated with the APOE genotype (p = 0.563, p = 0.605, p = 0.333 and p = 0.276, respectively). In addition, the T2D prevalence did not show an association with the APOE genotype (p = 0.354). Along the same lines, blood glucose levels and T2D prevalence did not show association with the APOE allele. Shift work had some effect on the glycaemic profile, showing that night shift workers have significantly lower levels of glucose, insulin and HOMA (p < 0.001). However, the APOE genotype did not show difference in the concentration of glycaemic parameters adjusting by sex, age and BMI, work shift and dietary parameters. Conclusion Glycemic profile and T2D prevalence did not show any significant association with the APOE genotype. Besides, individuals, who worked in non-rotating night shift showed significantly lower glycemic levels, while workers in the morning-afternoon-night shift showed significantly higher values. info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI19-00694 info:eu-repo/grantAgreement/ES/MINECO/PI18-01777 info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 0.424 2023 Pharmacology (medical) 2023 Q3 Cardiology and Cardiovascular Medicine 2023 Q3 3.2 2023 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Pérez-Calahorra, Sofía Universidad de Zaragoza (orcid)0000-0002-1894-1621 Bea, Ana M. Gracia-Rubio, Irene Universidad de Zaragoza (orcid)0000-0003-1028-8581 Rodrigo-Carbo, Carmen (orcid)0000-0002-1940-2208 Moreno-Franco, Belen Universidad de Zaragoza (orcid)0000-0003-0604-5042 Civeira, Fernando Universidad de Zaragoza (orcid)0000-0001-7043-0952 Laclaustra, Martín Universidad de Zaragoza (orcid)0000-0003-3963-0846 Lamiquiz-Moneo, Itziar Universidad de Zaragoza (orcid)0000-0002-9647-0108 1006 255 Universidad de Zaragoza Dpto. Fisiatría y Enfermería Área Enfermería 1003 027 Universidad de Zaragoza Dpto. Anatom.Histolog.Humanas Area Anatom.Embriol.Humana 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 1011 615 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Medic.Prevent.Salud Públ. 35, 5 (2023), 226-235 Clín. investig. arterioscler. Clinica e Investigacion en Arteriosclerosis 0214-9168 1408466 http://zaguan.unizar.es/record/126792/files/texto_completo.pdf Postprint 1434508 http://zaguan.unizar.es/record/126792/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:126792 articulos driver 2025-05-20-10:14:04 ARTICLE