Preliminary evaluation of the safety and efficacy of glucose solution infusion through the hepatic artery on irreversible electroporation focusing

Sarreshtehdari, Amirhossein ; Burdio, Fernando ; López-Alonso, Borja (Universidad de Zaragoza) ; Lucía, Óscar (Universidad de Zaragoza) ; Burdio, José Miguel (Universidad de Zaragoza) ; Villamonte, María ; Andaluz, A. ; García-Arnas, F. ; Berjano, E. ; Moll, Xavier

Resumen: Due to electrical features of the tissue, such as impedance, which have a significant impact on irreversible electroporation (IRE) function, the administration of glucose solution 5% (GS5%) through the hepatic artery would focus IRE on scattered liver tumors. By creating a differential impedance between healthy and tumor tissue. This study aimed to determine the effects of the GS5% protocol on healthy liver tissue and its safety. 21 male Athymic nude rats Hsd: RH-Foxn1mu were used in the study. Animals were split into two groups. In group 1, a continuous infusion through the gastroduodenal artery of GS5% was performed to measure the impedance with a dose of 0.008 mL/g for 16 min. In group 2, the animals were divided into two subgroups for infusions of GS5%. Group 2.1, at 0.008 mL/g for 16 min. Group 2.2 at 0.03 mL/g for 4 min. Blood samples were collected after anesthesia has been induced. The second sample, after catheterization of the artery, and the third after the GS5% infusion. All the animals were sacrificed to collect histological samples. The survival rate during the experiment was 100%. A considerable impact on the impedance of the tissue was noticed, on average up to 4.31 times more than the baseline, and no side effects were observed after GS5% infusion. In conclusion, impedance alteration by Glucose solution infusion may focus IRE on tumor tissue and decrease IRE’s effects on healthy tissue.

Idioma: Inglés

DOI: 10.1038/s41598-023-33487-3

Año: 2023

Publicado en: Scientific reports (Nature Publishing Group) 13 (2023), 7120 [9 pp.]
ISSN: 2045-2322

Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI17-0048
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI21-00440
Financiación: info:eu-repo/grantAgreement/ES/MINECO/RTI2018-094357-B-C21
Financiación: info:eu-repo/grantAgreement/ES/MINECO/RTI2018-094357-B-C22

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Tecnología Electrónica (Dpto. Ingeniería Electrón.Com.)