126855 20241125101154.0 doi 10.1038/s41598-023-33487-3 sideral 134206 ART-2023-134206 eng Sarreshtehdari, Amirhossein Preliminary evaluation of the safety and efficacy of glucose solution infusion through the hepatic artery on irreversible electroporation focusing 2023 Access copy available to the general public Unrestricted Due to electrical features of the tissue, such as impedance, which have a significant impact on irreversible electroporation (IRE) function, the administration of glucose solution 5% (GS5%) through the hepatic artery would focus IRE on scattered liver tumors. By creating a differential impedance between healthy and tumor tissue. This study aimed to determine the effects of the GS5% protocol on healthy liver tissue and its safety. 21 male Athymic nude rats Hsd: RH-Foxn1mu were used in the study. Animals were split into two groups. In group 1, a continuous infusion through the gastroduodenal artery of GS5% was performed to measure the impedance with a dose of 0.008 mL/g for 16 min. In group 2, the animals were divided into two subgroups for infusions of GS5%. Group 2.1, at 0.008 mL/g for 16 min. Group 2.2 at 0.03 mL/g for 4 min. Blood samples were collected after anesthesia has been induced. The second sample, after catheterization of the artery, and the third after the GS5% infusion. All the animals were sacrificed to collect histological samples. The survival rate during the experiment was 100%. A considerable impact on the impedance of the tissue was noticed, on average up to 4.31 times more than the baseline, and no side effects were observed after GS5% infusion. In conclusion, impedance alteration by Glucose solution infusion may focus IRE on tumor tissue and decrease IRE’s effects on healthy tissue. info:eu-repo/grantAgreement/ES/ISCIII/PI17-0048 info:eu-repo/grantAgreement/ES/ISCIII/PI21-00440 info:eu-repo/grantAgreement/ES/MINECO/RTI2018-094357-B-C21 info:eu-repo/grantAgreement/ES/MINECO/RTI2018-094357-B-C22 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 3.8 2023 MULTIDISCIPLINARY SCIENCES 25 / 134 = 0.187 2023 Q1 T1 0.9 2023 Multidisciplinary 2023 Q1 7.5 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Burdio, Fernando López-Alonso, Borja Universidad de Zaragoza (orcid)0000-0003-2848-170X Lucía, Óscar Universidad de Zaragoza (orcid)0000-0002-1284-9007 Burdio, José Miguel Universidad de Zaragoza (orcid)0000-0002-9655-5531 Villamonte, María Andaluz, A. García-Arnas, F. Berjano, E. Moll, Xavier 5008 785 Universidad de Zaragoza Dpto. Ingeniería Electrón.Com. Área Tecnología Electrónica 13 (2023), 7120 [9 pp.] Sci. rep. (Nat. Publ. Group) Scientific reports (Nature Publishing Group) 2045-2322 1477033 http://zaguan.unizar.es/record/126855/files/texto_completo.pdf Versión publicada 2419756 http://zaguan.unizar.es/record/126855/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:126855 articulos driver 2024-11-22-12:08:32 ARTICLE