000126908 001__ 126908
000126908 005__ 20241125101132.0
000126908 0247_ $$2doi$$a10.1016/j.neuroimage.2023.120188
000126908 0248_ $$2sideral$$a134307
000126908 037__ $$aART-2023-134307
000126908 041__ $$aeng
000126908 100__ $$aPo-Yu, F.
000126908 245__ $$aEEG responses induced by cerebellar TMS at rest and during visuomotor adaptation
000126908 260__ $$c2023
000126908 5060_ $$aAccess copy available to the general public$$fUnrestricted
000126908 5203_ $$aBackground: Connections between the cerebellum and the cortex play a critical role in learning and executing complex behaviours. Dual-coil transcranial magnetic stimulation (TMS) can be used non-invasively to probe connectivity changes between the lateral cerebellum and motor cortex (M1) using the motor evoked potential as an outcome measure (cerebellar-brain inhibition, CBI). However, it gives no information about cerebellar connections to other parts of cortex. Objectives: We used electroencephalography (EEG) to investigate whether it was possible to detect activity evoked in any areas of cortex by single-pulse TMS of the cerebellum (cerebellar TMS evoked potentials, cbTEPs). A second experiment tested if these responses were influenced by the performance of a cerebellar-dependent motor learning paradigm. Methods: In the first series of experiments, TMS was applied over either the right or left cerebellar cortex, and scalp EEG was recorded simultaneously. Control conditions that mimicked auditory and somatosensory inputs associated with cerebellar TMS were included to identify responses due to non-cerebellar sensory stimulation. We conducted a follow-up experiment that evaluated whether cbTEPs are behaviourally sensitive by assessing individuals before and after learning a visuomotor reach adaptation task. Results: A TMS pulse over the lateral cerebellum evoked EEG responses that could be distinguished from those caused by auditory and sensory artefacts. Significant positive (P80) and negative peaks (N110) over the contralateral frontal cerebral area were identified with a mirrored scalp distribution after left vs. right cerebellar stimulation. The P80 and N110 peaks were replicated in the cerebellar motor learning experiment and changed amplitude at different stages of learning. The change in amplitude of the P80 peak was associated with the degree of learning that individuals retained following adaptation. Due to overlap with sensory responses, the N110 should be interpreted with caution. Conclusions: Cerebral potentials evoked by TMS of the lateral cerebellum provide a neurophysiological probe of cerebellar function that complements the existing CBI method. They may provide novel insight into mechanisms of visuomotor adaptation and other cognitive processes.
000126908 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000126908 590__ $$a4.7$$b2023
000126908 592__ $$a2.436$$b2023
000126908 591__ $$aNEUROSCIENCES$$b63 / 310 = 0.203$$c2023$$dQ1$$eT1
000126908 593__ $$aNeurology$$c2023$$dQ1
000126908 591__ $$aNEUROIMAGING$$b1 / 15 = 0.067$$c2023$$dQ1$$eT1
000126908 593__ $$aCognitive Neuroscience$$c2023$$dQ1
000126908 591__ $$aRADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING$$b22 / 204 = 0.108$$c2023$$dQ1$$eT1
000126908 594__ $$a11.3$$b2023
000126908 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000126908 700__ $$aSpampinato, D.
000126908 700__ $$aMichell, K.
000126908 700__ $$aMancuso, M.
000126908 700__ $$aBrown, K.
000126908 700__ $$0(orcid)0000-0001-8439-151X$$aIbáñez, J.$$uUniversidad de Zaragoza
000126908 700__ $$aDi Santo, A.
000126908 700__ $$aLatorre, A.
000126908 700__ $$aBhatia, K.
000126908 700__ $$aRothwell, J. C
000126908 700__ $$aRocchi, L.
000126908 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000126908 773__ $$g275 (2023), 120188 [16 pp.]$$pNeuroImage$$tNEUROIMAGE$$x1053-8119
000126908 8564_ $$s4464992$$uhttps://zaguan.unizar.es/record/126908/files/texto_completo.pdf$$yVersión publicada
000126908 8564_ $$s2260219$$uhttps://zaguan.unizar.es/record/126908/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000126908 909CO $$ooai:zaguan.unizar.es:126908$$particulos$$pdriver
000126908 951__ $$a2024-11-22-11:59:20
000126908 980__ $$aARTICLE