000126921 001__ 126921
000126921 005__ 20241125101138.0
000126921 0247_ $$2doi$$a10.1021/acs.jpcc.3c00987
000126921 0248_ $$2sideral$$a134157
000126921 037__ $$aART-2023-134157
000126921 041__ $$aeng
000126921 100__ $$0(orcid)0000-0002-6399-0852$$aSánchez-Uriel, L.
000126921 245__ $$aHeterogeneous-driven glutathione oxidation: defining the catalytic role of chalcopyrite nanoparticles
000126921 260__ $$c2023
000126921 5060_ $$aAccess copy available to the general public$$fUnrestricted
000126921 5203_ $$aTransition-metal nanocatalysis represents a novel alternative currently experiencing flourishing progress to tackle the tumor microenvironment (TME) in cancer therapy. These nanomaterials aim at attacking tumor cells using the intrinsic selectivity of inorganic catalysts. In addition, special attention to tune and control the release of these transition metals is also required. Understanding the chemical reactions behind the catalytic action of the transition-metal nanocatalysts and preventing potential undesired side reactions caused by acute cytotoxicity of the released ionic species represent another important field of research. Specifically, copper-based oxides may suffer from acute leaching that potentially may induce toxicity not only to target cancer cells but also to nearby cells and tissues. In this work, we propose the synthesis of chalcopyrite (CuFeS2) nanostructures capable of triggering two key reactions for an effective chemodynamic therapy (CDT) in the heterogeneous phase: (i) glutathione (GSH) oxidation and (ii) oxidation of organic substrates using H2O2, with negligible leaching of metals under TME-like conditions. This represents an appealing alternative toward the development of safer copper–iron-based nanocatalytic materials with an active catalytic response without incurring leaching side phenomena.
000126921 536__ $$9info:eu-repo/grantAgreement/EUR/ERC/ERC-AdG-742684
000126921 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000126921 590__ $$a3.3$$b2023
000126921 592__ $$a0.957$$b2023
000126921 591__ $$aCHEMISTRY, PHYSICAL$$b82 / 178 = 0.461$$c2023$$dQ2$$eT2
000126921 593__ $$aPhysical and Theoretical Chemistry$$c2023$$dQ1
000126921 591__ $$aMATERIALS SCIENCE, MULTIDISCIPLINARY$$b196 / 439 = 0.446$$c2023$$dQ2$$eT2
000126921 593__ $$aElectronic, Optical and Magnetic Materials$$c2023$$dQ1
000126921 591__ $$aNANOSCIENCE & NANOTECHNOLOGY$$b79 / 141 = 0.56$$c2023$$dQ3$$eT2
000126921 593__ $$aSurfaces, Coatings and Films$$c2023$$dQ1
000126921 593__ $$aEnergy (miscellaneous)$$c2023$$dQ2
000126921 593__ $$aNanoscience and Nanotechnology$$c2023$$dQ2
000126921 594__ $$a6.5$$b2023
000126921 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000126921 700__ $$0(orcid)0000-0002-1791-0188$$aBonet-Aleta, J.$$uUniversidad de Zaragoza
000126921 700__ $$0(orcid)0000-0002-4599-3013$$aIbarra, A.
000126921 700__ $$0(orcid)0000-0002-4546-4111$$aHueso, J. L.$$uUniversidad de Zaragoza
000126921 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000126921 773__ $$g127, 29 (2023), 14146-14154$$pJ. phys. chem., C$$tJournal of physical chemistry. C.$$x1932-7447
000126921 8564_ $$s5427003$$uhttps://zaguan.unizar.es/record/126921/files/texto_completo.pdf$$yVersión publicada
000126921 8564_ $$s3150974$$uhttps://zaguan.unizar.es/record/126921/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000126921 909CO $$ooai:zaguan.unizar.es:126921$$particulos$$pdriver
000126921 951__ $$a2024-11-22-12:01:38
000126921 980__ $$aARTICLE