126921 20241125101138.0 doi 10.1021/acs.jpcc.3c00987 sideral 134157 ART-2023-134157 eng Sánchez-Uriel, L. (orcid)0000-0002-6399-0852 Heterogeneous-driven glutathione oxidation: defining the catalytic role of chalcopyrite nanoparticles 2023 Access copy available to the general public Unrestricted Transition-metal nanocatalysis represents a novel alternative currently experiencing flourishing progress to tackle the tumor microenvironment (TME) in cancer therapy. These nanomaterials aim at attacking tumor cells using the intrinsic selectivity of inorganic catalysts. In addition, special attention to tune and control the release of these transition metals is also required. Understanding the chemical reactions behind the catalytic action of the transition-metal nanocatalysts and preventing potential undesired side reactions caused by acute cytotoxicity of the released ionic species represent another important field of research. Specifically, copper-based oxides may suffer from acute leaching that potentially may induce toxicity not only to target cancer cells but also to nearby cells and tissues. In this work, we propose the synthesis of chalcopyrite (CuFeS2) nanostructures capable of triggering two key reactions for an effective chemodynamic therapy (CDT) in the heterogeneous phase: (i) glutathione (GSH) oxidation and (ii) oxidation of organic substrates using H2O2, with negligible leaching of metals under TME-like conditions. This represents an appealing alternative toward the development of safer copper–iron-based nanocatalytic materials with an active catalytic response without incurring leaching side phenomena. info:eu-repo/grantAgreement/EUR/ERC/ERC-AdG-742684 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 3.3 2023 CHEMISTRY, PHYSICAL 82 / 178 = 0.461 2023 Q2 T2 MATERIALS SCIENCE, MULTIDISCIPLINARY 196 / 439 = 0.446 2023 Q2 T2 NANOSCIENCE & NANOTECHNOLOGY 79 / 141 = 0.56 2023 Q3 T2 0.957 2023 Physical and Theoretical Chemistry 2023 Q1 Electronic, Optical and Magnetic Materials 2023 Q1 Surfaces, Coatings and Films 2023 Q1 Energy (miscellaneous) 2023 Q2 Nanoscience and Nanotechnology 2023 Q2 6.5 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Bonet-Aleta, J. Universidad de Zaragoza (orcid)0000-0002-1791-0188 Ibarra, A. (orcid)0000-0002-4599-3013 Hueso, J. L. Universidad de Zaragoza (orcid)0000-0002-4546-4111 5005 555 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Ingeniería Química 127, 29 (2023), 14146-14154 J. phys. chem., C Journal of physical chemistry. C. 1932-7447 5427003 http://zaguan.unizar.es/record/126921/files/texto_completo.pdf Versión publicada 3150974 http://zaguan.unizar.es/record/126921/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:126921 articulos driver 2024-11-22-12:01:38 ARTICLE