000126939 001__ 126939 000126939 005__ 20241125101140.0 000126939 0247_ $$2doi$$a10.3389/fpsyt.2023.1163800 000126939 0248_ $$2sideral$$a134426 000126939 037__ $$aART-2023-134426 000126939 041__ $$aeng 000126939 100__ $$aBellón, Juan A. 000126939 245__ $$aA personalized intervention to prevent depression in primary care based on risk predictive algorithms and decision support systems: protocol of the e-predictD study 000126939 260__ $$c2023 000126939 5060_ $$aAccess copy available to the general public$$fUnrestricted 000126939 5203_ $$aThe predictD is an intervention implemented by general practitioners (GPs) to prevent depression, which reduced the incidence of depression-anxiety and was cost-effective. The e-predictD study aims to design, develop, and evaluate an evolved predictD intervention to prevent the onset of major depression in primary care based on Information and Communication Technologies, predictive risk algorithms, decision support systems (DSSs), and personalized prevention plans (PPPs). A multicenter cluster randomized trial with GPs randomly assigned to the e-predictD intervention + care-as-usual (CAU) group or the active-control + CAU group and 1-year follow-up is being conducted. The required sample size is 720 non-depressed patients (aged 18–55 years), with moderate-to-high depression risk, under the care of 72 GPs in six Spanish cities. The GPs assigned to the e-predictD-intervention group receive brief training, and those assigned to the control group do not. Recruited patients of the GPs allocated to the e-predictD group download the e-predictD app, which incorporates validated risk algorithms to predict depression, monitoring systems, and DSSs. Integrating all inputs, the DSS automatically proposes to the patients a PPP for depression based on eight intervention modules: physical exercise, social relationships, improving sleep, problem-solving, communication skills, decision-making, assertiveness, and working with thoughts. This PPP is discussed in a 15-min semi-structured GP-patient interview. Patients then choose one or more of the intervention modules proposed by the DSS to be self-implemented over the next 3 months. This process will be reformulated at 3, 6, and 9 months but without the GP–patient interview. Recruited patients of the GPs allocated to the control-group+CAU download another version of the e-predictD app, but the only intervention that they receive via the app is weekly brief psychoeducational messages (active-control group). The primary outcome is the cumulative incidence of major depression measured by the Composite International Diagnostic Interview at 6 and 12 months. Other outcomes include depressive symptoms (PHQ-9) and anxiety symptoms (GAD-7), depression risk (predictD risk algorithm), mental and physical quality of life (SF-12), and acceptability and satisfaction (‘e-Health Impact' questionnaire) with the intervention. Patients are evaluated at baseline and 3, 6, 9, and 12 months. An economic evaluation will also be performed (cost-effectiveness and cost-utility analysis) from two perspectives, societal and health systems.Trial registrationClinicalTrials.gov, identifier: NCT03990792. 000126939 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII-RedIAPP/RD16-0007-0001$$9iinfo:eu-repo/grantAgreement/ES/ISCIII-RedIAPP/RD16-0007-0003$$9info:eu-repo/grantAgreement/ES/ISCIII-RedIAPP/RD16-0007-0005$$9iinfo:eu-repo/grantAgreement/ES/ISCIII-RedIAPP/RD16-0007-0010$$9info:eu-repo/grantAgreement/ES/ISCIII-RICAPPS/RD21-0016-0001$$9info:eu-repo/grantAgreement/ES/ISCIII-RICAPPS/RD21-0016-0005$$9info:eu-repo/grantAgreement/ES/ISCIII-RICAPPS/RD21-0016-0010$$9info:eu-repo/grantAgreement/ES/ISCIII-RICAPPS/RD21-0016-0012$$9info:eu-repo/grantAgreement/ES/MSCBS-ISCIII-FEDER/Una manera de hacer Europa-PI15-00401$$9info:eu-repo/grantAgreement/ES/MSCBS-ISCIII-FEDER/Una manera de hacer Europa-PI15-01021$$9info:eu-repo/grantAgreement/ES/MSCBS-ISCIII-FEDER/Una manera de hacer Europa-PI15-01035 000126939 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000126939 590__ $$a3.2$$b2023 000126939 592__ $$a1.155$$b2023 000126939 591__ $$aPSYCHIATRY$$b88 / 279 = 0.315$$c2023$$dQ2$$eT1 000126939 593__ $$aPsychiatry and Mental Health$$c2023$$dQ1 000126939 591__ $$aPSYCHIATRY$$b88 / 279 = 0.315$$c2023$$dQ2$$eT1 000126939 594__ $$a6.2$$b2023 000126939 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000126939 700__ $$aRodríguez-Morejón, Alberto 000126939 700__ $$aConejo-Cerón, Sonia 000126939 700__ $$aCampos-Paíno, Henar 000126939 700__ $$aRodríguez-Bayón, Antonina 000126939 700__ $$aBallesta-Rodríguez, María I. 000126939 700__ $$aRodríguez-Sánchez, Emiliano 000126939 700__ $$aMendive, Juan M. 000126939 700__ $$0(orcid)0000-0002-1690-4130$$aLópez del Hoyo, Yolanda$$uUniversidad de Zaragoza 000126939 700__ $$aLuna, Juan D. 000126939 700__ $$aTamayo-Morales, Olaya 000126939 700__ $$aMoreno-Peral, Patricia 000126939 7102_ $$14009$$2730$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicología Básica 000126939 773__ $$g14 (2023), [22 pp.]$$tFrontiers in Psychiatry$$x1664-0640 000126939 8564_ $$s3295859$$uhttps://zaguan.unizar.es/record/126939/files/texto_completo.pdf$$yVersión publicada 000126939 8564_ $$s2406738$$uhttps://zaguan.unizar.es/record/126939/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000126939 909CO $$ooai:zaguan.unizar.es:126939$$particulos$$pdriver 000126939 951__ $$a2024-11-22-12:02:27 000126939 980__ $$aARTICLE