126944 20241125101142.0 doi 10.1016/j.bioelechem.2023.108510 sideral 134439 ART-2023-134439 eng Briz, P. Universidad de Zaragoza (orcid)0000-0002-6768-5177 Tumor location on electroporation therapies by means of multi-electrode structures and machine learning 2023 Access copy available to the general public Unrestricted Electroporation is a phenomenon produced in the cell membrane when it is exposed to high pulsed electric fields that increases its permeability. Among other application fields, this phenomenon can be exploited in a clinical environment for tumor ablation therapies. In this context to achieve optimum results, it is convenient to focus the treatment on the tumor tissue to minimize side effects. In this work, a pre-treatment tumor location method is developed, with the purpose of being able to precisely target the therapy. This is done by taking different impedance measurements with a multi-output electroporation generator in conjunction with a multi-electrode structure. Data are processed by means of a vector of independent artificial neural networks, trained and tested with simulation data, and validated with phantom gels. This algorithm proved to provide suitable accuracy in spite of the low electrode count compared to the number of electrodes of a standard electrical impedance tomography device. info:eu-repo/grantAgreement/EUR/AEI/TED2021-129274B-I00 info:eu-repo/grantAgreement/ES/ISCIII/PI21-00440 info:eu-repo/grantAgreement/ES/MICINN-AEI-FEDER/PID2019-103939RB-I00 info:eu-repo/grantAgreement/ES/MICINN-AEI/PDC2021-120898-I00 info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 4.8 2023 BIOCHEMISTRY & MOLECULAR BIOLOGY 67 / 313 = 0.214 2023 Q1 T1 BIOLOGY 14 / 109 = 0.128 2023 Q1 T1 BIOPHYSICS 10 / 77 = 0.13 2023 Q1 T1 ELECTROCHEMISTRY 14 / 45 = 0.311 2023 Q2 T1 0.705 2023 Biophysics 2023 Q2 Physical and Theoretical Chemistry 2023 Q2 Medicine (miscellaneous) 2023 Q2 Electrochemistry 2023 Q2 9.1 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion López-Alonso, B. Universidad de Zaragoza (orcid)0000-0003-2848-170X Sarnago, H. Universidad de Zaragoza (orcid)0000-0001-8399-4650 Burdío, J.M. Universidad de Zaragoza (orcid)0000-0002-9655-5531 Lucía, O. Universidad de Zaragoza (orcid)0000-0002-1284-9007 5008 785 Universidad de Zaragoza Dpto. Ingeniería Electrón.Com. Área Tecnología Electrónica 154 (2023), 108510 [7 pp.] BIOELECTROCHEMISTRY Bioelectrochemistry 1567-5394 4649446 http://zaguan.unizar.es/record/126944/files/texto_completo.pdf Versión publicada 2573332 http://zaguan.unizar.es/record/126944/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:126944 articulos driver 2024-11-22-12:02:52 ARTICLE