000126970 001__ 126970
000126970 005__ 20241125101143.0
000126970 0247_ $$2doi$$a10.1364/BOE.489054
000126970 0248_ $$2sideral$$a134440
000126970 037__ $$aART-2023-134440
000126970 041__ $$aeng
000126970 100__ $$aMiazdzyk, Maria
000126970 245__ $$aOCT based corneal densitometry: the confounding effect of epithelial speckle
000126970 260__ $$c2023
000126970 5060_ $$aAccess copy available to the general public$$fUnrestricted
000126970 5203_ $$aCorneal densitometry is a clinically validated method for objectively assessing the transparency of stroma. The technique is currently dominated by Scheimpflug technology. Still, optical coherence tomography (OCT), in which examination of the statistical properties of corneal speckle is undertaken, has also been considered to assess corneal densitometry. In-vivo, the stroma is observed via the epithelium. However, the effect of this external layer on stromal densitometry has not been considered as yet. This study aims to quantify the influence of epithelium integrity on corneal OCT densitometry. OCT images from eleven freshly enucleated porcine eyes before and after epithelial debridement were used. OCT densitometry was investigated at different stromal depths using four metrics of speckle statistics. Results indicate that there exist statistically significant differences in speckle statistics for a given stromal depth depending on the presence or absence of the epithelium. The estimation error in speckle statistics can reach over 20% depending on the stromal depth. The anterior stroma densitometry values are the ones most affected by epithelial integrity. In conclusion, if OCT densitometry stromal parameters are to be considered in absolute terms, it is essential to consider the confounding effect of the epithelial layer in the analysis.
000126970 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000126970 590__ $$a2.9$$b2023
000126970 592__ $$a0.925$$b2023
000126970 591__ $$aBIOCHEMICAL RESEARCH METHODS$$b33 / 85 = 0.388$$c2023$$dQ2$$eT2
000126970 593__ $$aBiotechnology$$c2023$$dQ1
000126970 591__ $$aRADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING$$b60 / 204 = 0.294$$c2023$$dQ2$$eT1
000126970 593__ $$aAtomic and Molecular Physics, and Optics$$c2023$$dQ1
000126970 591__ $$aOPTICS$$b41 / 119 = 0.345$$c2023$$dQ2$$eT2
000126970 594__ $$a6.8$$b2023
000126970 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000126970 700__ $$0(orcid)0000-0001-5186-1837$$aConsejo, Alejandra$$uUniversidad de Zaragoza
000126970 700__ $$aIskander, D. Robert
000126970 7102_ $$12002$$2385$$aUniversidad de Zaragoza$$bDpto. Física Aplicada$$cÁrea Física Aplicada
000126970 773__ $$g14, 8 (2023), 3871-3880$$pBIOMEDICAL OPTICS EXPRESS$$tBiomedical Optics Express$$x2156-7085
000126970 8564_ $$s3693904$$uhttps://zaguan.unizar.es/record/126970/files/texto_completo.pdf$$yVersión publicada
000126970 8564_ $$s2446219$$uhttps://zaguan.unizar.es/record/126970/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000126970 909CO $$ooai:zaguan.unizar.es:126970$$particulos$$pdriver
000126970 951__ $$a2024-11-22-12:03:23
000126970 980__ $$aARTICLE