Update on commonly used molecular typing methods for Clostridioides Difficile

Abad-Fau, Ana (Universidad de Zaragoza) ; Sevilla, Eloísa (Universidad de Zaragoza) ; Martín-Burriel, Inmaculada (Universidad de Zaragoza) ; Moreno, Bernardino (Universidad de Zaragoza) ; Bolea, Rosa (Universidad de Zaragoza)
Update on commonly used molecular typing methods for Clostridioides Difficile
Resumen: This review aims to provide a comprehensive overview of the significant Clostridioides difficile molecular typing techniques currently employed in research and medical communities. The main objectives of this review are to describe the key molecular typing methods utilized in C. difficile studies and to highlight the epidemiological characteristics of the most prevalent strains on a global scale. Geographically distinct regions exhibit distinct strain types of C. difficile, with notable concordance observed among various typing methodologies. The advantages that next-generation sequencing (NGS) offers has changed epidemiology research, enabling high-resolution genomic analyses of this pathogen. NGS platforms offer an unprecedented opportunity to explore the genetic intricacies and evolutionary trajectories of C. difficile strains. It is relevant to acknowledge that novel routes of transmission are continually being unveiled and warrant further investigation, particularly in the context of zoonotic implications and environmental contamination.
Idioma: Inglés
DOI: 10.3390/microorganisms11071752
Año: 2023
Publicado en: Microorganisms 11, 7 (2023), 1752 [24 pp.]
ISSN: 2076-2607

Financiación: info:eu-repo/grantAgreement/ES/UZ-OTRI/2018-0460
Tipo y forma: Review (Published version)
Área (Departamento): Área Genética (Dpto. Anatom.,Embri.Genét.Ani.)
Área (Departamento): Área Sanidad Animal (Dpto. Patología Animal)

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 Record created 2023-08-30, last modified 2023-10-06

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