000126977 001__ 126977
000126977 005__ 20241125101146.0
000126977 0247_ $$2doi$$a10.1017/neu.2023.9
000126977 0248_ $$2sideral$$a133547
000126977 037__ $$aART-2023-133547
000126977 041__ $$aeng
000126977 100__ $$aVerdolini, N.
000126977 245__ $$aObstetric complications and clinical presentation in first episode of psychosis
000126977 260__ $$c2023
000126977 5060_ $$aAccess copy available to the general public$$fUnrestricted
000126977 5203_ $$aObjective: Psychotic disorders exhibit a complex aetiology that combines genetic and environmental factors. Among the latter, obstetric complications (OCs) have been widely studied as risk factors, but it is not yet well understood how OCs relate to the heterogeneous presentations of psychotic disorders. We assessed the clinical phenotypes of individuals with a first episode of psychosis (FEP) in relation to the presence of OCs. Methods: Two-hundred seventy-seven patients with an FEP were assessed for OCs using the Lewis–Murray scale, with data stratified into three subscales depending on the timing and the characteristics of the obstetric event, namely: complications of pregnancy, abnormal foetal growth and development and difficulties in delivery. We also considered other two groups: any complications during the pregnancy period and all OCs taken altogether. Patients were clinically evaluated with the Positive and Negative Syndrome Scale for schizophrenia. Results: Total OCs and difficulties in delivery were related to more severe psychopathology, and this remained significant after co-varying for age, sex, traumatic experiences, antipsychotic dosage and cannabis use. Conclusions: Our results highlight the relevance of OCs for the clinical presentation of psychosis. Describing the timing of the OCs is essential in understanding the heterogeneity of the clinical presentation.
000126977 536__ $$9info:eu-repo/grantAgreement/EC/H2020/754550/EU/Biomedicine international training research programme for excellent clinician-scientists/BITRECS$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 754550-BITRECS$$9info:eu-repo/grantAgreement/ES/ISCIII/PI20-00661$$9info:eu-repo/grantAgreement/ES/MINECO/PI08-0208$$9info:eu-repo/grantAgreement/ES/MINECO/PI11-00325$$9info:eu-repo/grantAgreement/ES/MINECO/PI14-00612
000126977 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000126977 590__ $$a2.6$$b2023
000126977 592__ $$a0.874$$b2023
000126977 591__ $$aPSYCHIATRY$$b115 / 279 = 0.412$$c2023$$dQ2$$eT2
000126977 593__ $$aPsychiatry and Mental Health$$c2023$$dQ2
000126977 591__ $$aNEUROSCIENCES$$b176 / 310 = 0.568$$c2023$$dQ3$$eT2
000126977 593__ $$aBiological Psychiatry$$c2023$$dQ3
000126977 594__ $$a8.5$$b2023
000126977 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000126977 700__ $$aMezquida, G.
000126977 700__ $$aValli, I.
000126977 700__ $$aGarcía-Rizo, C.
000126977 700__ $$aCuesta, M.
000126977 700__ $$aVieta, E.
000126977 700__ $$aBioque, M.
000126977 700__ $$0(orcid)0000-0002-9098-655X$$aLobo, A.$$uUniversidad de Zaragoza
000126977 700__ $$aGonzález-Pinto, A.
000126977 700__ $$aPina-Camacho, L.
000126977 700__ $$aCorripio, I.
000126977 700__ $$aGarriga, M.
000126977 700__ $$aBaeza, I.
000126977 700__ $$aMartínez-Sadurní, L.
000126977 700__ $$aBitanihirwe, B.
000126977 700__ $$aCannon, M.
000126977 700__ $$aBernardo, M.
000126977 700__ $$0(orcid)0000-0003-2284-7862$$aDe la Cámara, C.$$uUniversidad de Zaragoza
000126977 700__ $$0(orcid)0000-0001-5940-0357$$aRuiz-Lázaro, P. M.$$uUniversidad de Zaragoza
000126977 700__ $$aPEPs Group
000126977 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Psiquiatría
000126977 773__ $$g35, 3 (2023), 156-164$$pActa neuropsychiatr.$$tACTA NEUROPSYCHIATRICA$$x0924-2708
000126977 8564_ $$s378319$$uhttps://zaguan.unizar.es/record/126977/files/texto_completo.pdf$$yVersión publicada
000126977 8564_ $$s2896717$$uhttps://zaguan.unizar.es/record/126977/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000126977 909CO $$ooai:zaguan.unizar.es:126977$$particulos$$pdriver
000126977 951__ $$a2024-11-22-12:04:34
000126977 980__ $$aARTICLE