127017 20241125101155.0 doi 10.1113/JP281885 sideral 134340 ART-2023-134340 eng Spampinato, Danny Adrian Motor potentials evoked by transcranial magnetic stimulation: interpreting a simple measure of a complex system 2023 Access copy available to the general public Unrestricted Transcranial magnetic stimulation (TMS) is a non‐invasive technique that is increasingly used to study the human brain. One of the principal outcome measures is the motor‐evoked potential (MEP) elicited in a muscle following TMS over the primary motor cortex (M1), where it is used to estimate changes in corticospinal excitability. However, multiple elements play a role in MEP generation, so even apparently simple measures such as peak‐to‐peak amplitude have a complex interpretation. Here, we summarize what is currently known regarding the neural pathways and circuits that contribute to the MEP and discuss the factors that should be considered when interpreting MEP amplitude measured at rest in the context of motor processing and patients with neurological conditions. In the last part of this work, we also discuss how emerging technological approaches can be combined with TMS to improve our understanding of neural substrates that can influence MEPs. Overall, this review aims to highlight the capabilities and limitations of TMS that are important to recognize when attempting to disentangle sources that contribute to the physiological state‐related changes in corticomotor excitability. info:eu-repo/grantAgreement/ES/MICINN/RYC2021-031905-I info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.7 2023 PHYSIOLOGY 10 / 85 = 0.118 2023 Q1 T1 NEUROSCIENCES 63 / 310 = 0.203 2023 Q1 T1 1.708 2023 Sports Science 2023 Q1 Physiology 2023 Q1 9.7 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Ibáñez, Jaime Universidad de Zaragoza (orcid)0000-0001-8439-151X Rocchi, Lorenzo Rothwell, John 5008 800 Universidad de Zaragoza Dpto. Ingeniería Electrón.Com. Área Teoría Señal y Comunicac. 601, 14 (2023), 2827-2851 J. physiol. JOURNAL OF PHYSIOLOGY-LONDON 0022-3751 1131920 http://zaguan.unizar.es/record/127017/files/texto_completo.pdf Versión publicada 1920044 http://zaguan.unizar.es/record/127017/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:127017 articulos driver 2024-11-22-12:08:39 ARTICLE