000127095 001__ 127095 000127095 005__ 20241125101146.0 000127095 0247_ $$2doi$$a10.1371/journal.pone.0288581 000127095 0248_ $$2sideral$$a134494 000127095 037__ $$aART-2023-134494 000127095 041__ $$aeng 000127095 100__ $$0(orcid)0000-0001-9411-5834$$aViladés, Elisa$$uUniversidad de Zaragoza 000127095 245__ $$aEvaluation of multiple sclerosis severity using a new OCT tool 000127095 260__ $$c2023 000127095 5060_ $$aAccess copy available to the general public$$fUnrestricted 000127095 5203_ $$aPurpose: To assess the ability of a new posterior pole protocol to detect areas with significant differences in retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) thickness in patients with multiple sclerosis versus healthy control subjects; in addition, to assess the correlation between RNFL and GCL thickness, disease duration, and the Expanded Disability Status Scale (EDSS). Methods: We analyzed 66 eyes of healthy control subjects and 100 eyes of remitting-relapsing multiple sclerosis (RR-MS) patients. Double analysis based on first clinical symptom onset (CSO) and conversion to clinically definite MS (CDMS) was performed. The RR-MS group was divided into subgroups by CSO and CDMS year: CSO-1 (≤ 5 years) and CSO-2 (≥ 6 years), and CDMS-1 (≤ 5 years) and CDMS-2 (≥ 6 years). Results: Significant differences in RNFL and GCL thickness were found between the RR-MS group and the healthy controls and between the CSO and CDMS subgroups and in both layers. Moderate to strong correlations were found between RNFL and GCL thickness and CSO and CDMS. Furthermore, we observed a strong correlation with EDSS 1 year after the OCT examination. Conclusions: The posterior pole protocol is a useful tool for assessing MS and can reveal differences even in early stages of the disease. RNFL thickness shows a strong correlation with disability status, while GCL thickness correlates better with disease duration. 000127095 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/PI17-01726$$9info:eu-repo/grantAgreement/ES/ISCIII/PI20-00437$$9info:eu-repo/grantAgreement/ES/ISCIII-RICORDS/RD21-0002-0050 000127095 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000127095 590__ $$a2.9$$b2023 000127095 592__ $$a0.839$$b2023 000127095 591__ $$aMULTIDISCIPLINARY SCIENCES$$b32 / 134 = 0.239$$c2023$$dQ1$$eT1 000127095 593__ $$aMultidisciplinary$$c2023$$dQ1 000127095 594__ $$a6.2$$b2023 000127095 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000127095 700__ $$aCordón, Beatriz$$uUniversidad de Zaragoza 000127095 700__ $$aPérez-Velilla, Javier 000127095 700__ $$aOrduna, Elvira$$uUniversidad de Zaragoza 000127095 700__ $$0(orcid)0000-0002-1609-5994$$aSatue, Maria$$uUniversidad de Zaragoza 000127095 700__ $$0(orcid)0000-0002-1402-3129$$aPolo, Vicente$$uUniversidad de Zaragoza 000127095 700__ $$aSebastian, Berta 000127095 700__ $$0(orcid)0000-0002-6745-7668$$aLarrosa, Jose Manuel$$uUniversidad de Zaragoza 000127095 700__ $$0(orcid)0000-0003-2389-8282$$aPablo, Luis$$uUniversidad de Zaragoza 000127095 700__ $$0(orcid)0000-0001-6258-2489$$aGarcía-Martin, Elena$$uUniversidad de Zaragoza 000127095 7102_ $$11013$$2090$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Cirugía 000127095 7102_ $$11013$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Oftalmología 000127095 773__ $$g18, 7 (2023), e0288581 [14 pp]$$pPLoS One$$tPLoS ONE$$x1932-6203 000127095 8564_ $$s2253404$$uhttps://zaguan.unizar.es/record/127095/files/texto_completo.pdf$$yVersión publicada 000127095 8564_ $$s1996014$$uhttps://zaguan.unizar.es/record/127095/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000127095 909CO $$ooai:zaguan.unizar.es:127095$$particulos$$pdriver 000127095 951__ $$a2024-11-22-12:04:36 000127095 980__ $$aARTICLE